| Zhou Wanyi,Hu Ankang,Qiu Rui,Li Junli.Research progress of the mechanism of Flash effect[J].Chinese Journal of Radiological Medicine and Protection,2023,43(2):143-148 |
| Research progress of the mechanism of Flash effect |
| Received:August 31, 2022 |
| DOI：10.3760/cma.j.cn112271-20220831-00355 |
| KeyWords:Flash radiotherapy Mechanism Hypothesis |
| FundProject:国家自然科学基金（12175114，11875036）；国家重点研发计划（2021YFF0603600）；清华大学自主科研项目（20211080081） |
| Author Name | Affiliation | E-mail | | Zhou Wanyi | Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China | | | Hu Ankang | Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China | | | Qiu Rui | Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China | qiurui@tsinghua.edu.cn | | Li Junli | Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China | |
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| Abstract:: |
| The ultra-high dose rate (UHDR) radiation has less side effect while keep comparable tumor control effect with conventional dose rate (CONV) radiation, which was named Flash effect. Recently, the Flash effect has been reported in many animal experiments with various types of radiations, animal species and body parts. However, the underlying mechanism of Flash has still been unraveled, making difficulties for the clinical application. This review pointed out the differences between the Flash effect and the UHDR effect in vitro and proposed three key scientific questions of Flash effect based on three well-known hypotheses, i.e., oxygen depletion, peroxyl radical recombination and immune cell protection. Finally, the research progresses and challenges of Flash mechanism study are concluded in order to give a clue for further deep investigation. |
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