| Wu Di,Wang Ping,Han Lin,et al.Analysis of chromosome aberration in peripheral blood lymphocytes of underground miners in non-uranium metal mines[J].Chinese Journal of Radiological Medicine and Protection,2022,42(12):915-921 |
| Analysis of chromosome aberration in peripheral blood lymphocytes of underground miners in non-uranium metal mines |
| Received:September 01, 2022 |
| DOI：10.3760/cma.j.cn112271-20220901-00356 |
| KeyWords:Non-uranium metal mines|Underground miners|Peripheral blood lymphocytes|Chromosomal aberrations |
| FundProject:河南省医学科技攻关计划项目(LHGJ20190815);中国医学科学院放射医学研究所辐射生物剂量与生物标志物联合实验室项目(JSQTHTKT20200901664) |
| Author Name | Affiliation | E-mail | | Wu Di | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Wang Ping | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Han Lin | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhao Yanfang | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhao Zuchang | Sanmenxia City Center for Disease Control and Prevention, Sanmenxia 472000, China | | | Li Jie | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Du Shasha | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Wang Xiai | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhang Yunfei | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhao Fengling | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Lyu Yumin | The Third People's Hospital of Henan Province, Henan Occupational Disease Hospital, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | lym636160@sina.com |
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| Abstract:: |
| Objective To investigate chromosomal aberrations in peripheral blood lymphocytes of underground miners, in order to explore the influencing factors involved in chromosomal aberration levels of non-uranium metal mines.Methods Totall 135 workers were recruited from an iron mine and a gold mine located in different cities of Henan province, where 69 workers worked aboveground and 66 miners worked underground in the metal mines. The radon concentration in the mines was measured by solid-state nuclear track detectors. Chromosomal aberrations in peripheral blood lymphocytes from the subjects were detected using conventional analysis method, and the influence factors of chromosomal aberrations were analyzed.Results Radon concentration was 30-2 943 Bq/m3 in the aboveground workplace of the mines, and 62-28 314 Bq/m3 in underground. The age of the underground group was obviously lower than that of the aboveground group(t=2.12, P<0.05), but the frequencies of dicentrics, translocation, acentric fragment, and total chromosome-type aberrations in the underground group were significantly higher than those in the aboveground group (χ2=10.49, 16.74, 8.15, 29.50, P<0.01). Consistent results were obtained when only male workers were regarded as object of observation (χ2=8.44, 11.63, 4.94, 20.81, P<0.05). The frequency of translocation (χ2=8.44, P<0.05) was dependent on the length of service in the underground group. Poisson regression analysis indicated that the aboveground and undergroud grouping partly affected the levels of dicentrics, translocation, acentric fragment, and total chromosome-type aberrations (the underground group IRR=3.25, 2.69, 1.97, 2.18, P<0.05).Conclusions The radon exposure in the underground workplace of the metal mines may be the main factor resulting in the increase of chromosome-type aberrations of miners. The occupational health and safety of the miners who may be exposed to high radon levels are worthy of great attention. |
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