| Chen Paihan,Zou Jianming,Chen Huifeng,Chen Kengkeng,Cui Fan,Huang Weixu.Analysis of blood lipid levels and its influencing factors in male residents around an uranium mine[J].Chinese Journal of Radiological Medicine and Protection,2022,42(2):121-129 |
| Analysis of blood lipid levels and its influencing factors in male residents around an uranium mine |
| Received:June 29, 2021 |
| DOI：10.3760/cma.j.cn112271-20210629-00259 |
| KeyWords:Uranium mine Serum lipid levels Dyslipidemia Health risk assessment |
| FundProject:国家自然科学基金（81302387）；广东省职业病防治重点实验室（2017B030314152）；广东省自然科学基金（2019A1515011969） |
| Author Name | Affiliation | E-mail | | Chen Paihan | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | | | Zou Jianming | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | zjm990916@126.com | | Chen Huifeng | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | | | Chen Kengkeng | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | | | Cui Fan | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | | | Huang Weixu | Guangdong Province Hospital for Occupational Disease Prevention and treatment, Guangdong Key Laboratory of Occupational Disease Prevention and Control, Guangzhou, Guangdong 510300, China | |
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| Abstract:: |
| Objective To analyze the serum lipid levels, and its influencing factors, of male residents around an uranium mine in order to provide a scientific basis for health risk assessment for such residents. Methods With such a mine as the center, the surveyed subjects were divided into four groups as within 5, 10, 15 and 20 km of this mine, respectively. These male residents living around the mine were randomly selected as subjects. A health questionnaire survey was conducted among the subjects. The indicator such as height, weight and blood pressure were measured by means of the standard method. Peripheral venous blood was extracted from the subjects, and their venous blood glucose and serum lipid were detected. The levels of serum lipid and detectable rates of abnormal serum lipid were analyzed by using univariate analysis, and multivariate logistic regression analysis was used to analyze the influencing factors of dyslipidemia. Results A total of 867 males at age 40 to 69 was included in the vicinity of the mine. The mean levels (x±s) of TC, TG, LDL-C, and HDL-C were (5.46±1.11), (1.92±1.64), (3.19±1.02), and (1.39±0.43) mmol/L, respectively. 384 subjects with dyslipidemia were totally detected in the residents, and the detection rate was 44.29% (384/867). Of the residents with dyslipidemia, the majority was abnormal in two lipid related indexes (45.57%, 175/384). Univariate analysis result showed that there was statistically significant difference in TG level in different distance groups (F=3.34, P<0.05). There were statistically significant differences in the abnormal detection rates of TG and HDL-C in subjects in different distance groups (χ2=9.52, 10.18, P<0.05). The detection rates of dyslipidemia were significantly different in the groups of BMI, blood pressure and blood glucose (χ2=45.91, 32.31, 11.42, P<0.05). Multivariate logistic regression analysis showed that excluding marital status and degree of education, the BMI, blood pressure and blood glucose all had an impact on dyslipidemia. The residents with overweight (OR=2.08, 95%CI: 1.52-2.86) and obeseness (OR=2.88, 95%CI: 1.58-5.24) had a higher risk for dyslipidemia than those with normal weight. The risks for dyslipidemia in the residents with hypertension (OR=1.94, 95%CI: 1.45-2.60) and hyperglycemia (OR=2.17, 95%CI: 1.27-3.69) were higher than those with normal blood pressure and blood glucose, respectively. Conclusions The detection rate of dyslipidemia is higher in male residents around the mine. The BMI, alcohol consumption, blood pressure, blood glucose and distance from the mine are influencing dyslipidemia and other relevant indexes. Overweight is an independent risk factor for dyslipidemia and its components. The distances from uranium mine has no significant effect on the dyslipidemia of male residents. |
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