| Chen Wenping,Yin Kejie,Li Ming,et al.Feasibility study of reducing the radiation dose on virtual non-contrast scanning in dual-layer spectral coronary CT angiography[J].Chinese Journal of Radiological Medicine and Protection,2022,42(1):61-66 |
| Feasibility study of reducing the radiation dose on virtual non-contrast scanning in dual-layer spectral coronary CT angiography |
| Received:August 19, 2021 |
| DOI：10.3760/cma.j.cn112271-20210819-00336 |
| KeyWords:Computed Tomography Coronary artery Vascular calcification Radiation dose Virtual non-contrast |
| FundProject:中国博士后科学基金（2019M661804）；江苏省博士后科学基金（2019k060）；南京市医学科学技术发展基金（ZKX19018、QRX17057）；南京鼓楼医院新技术发展基金（XJSFZJJ202026） |
| Author Name | Affiliation | E-mail | | Chen Wenping | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Yin Kejie | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Li Ming | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Kang lina | Department of Cardiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Yu Hongming | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Liang Jing | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | | | Wu Min | Department of Radiology, Tongren People's Hospital, Guizhou Province, Guiyang 554300, China | | | Kashif Dar | Department of Cardiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China | | | Chen Xingbiao | Clinical Science, Philips Healthcare, Shanghai 200070, China | | | Sheng Zhihong | Clinical Science, Philips Healthcare, Shanghai 200070, China | | | Mu Dan | Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China | mudan118@126.com |
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| Abstract:: |
| Objective To investigate the feasibility of reducing the radiation dose on coronary artery calcium score (CS) of virtual non-contrast (VNC) scanning in dual-layer spectral coronary CT angiography(CCTA).Methods One hundred and twenty-two patients were examined on a dual-layer spectral detector CT scanner from March 2019 to August 2020. Volume CT dose index (CTDIvol), dose length product (DLP), effective dose (E) were all evaluated for each patient. CS was calculated from both true non-contrast (TNC) and VNC images for left anterior descending (LAD), left circumflex (LCx), right coronary artery (RCA), and the total coronary artery (Total) by two radiologists independently. Pearson's correlation coefficient was calculated for measuring the association between variables. The correction coefficients of each branch (λLAD, λLCx, and λRCA) and the average correction coefficient (λAVG) of the total coronary artery were obtained. The calibrated calcium score (CCS_VNC) was equal to λ multiplied by CS_VNC. The CS_TNC and CCS_VNC were compared using repeated oneway analysis of variance test. Correlation analyses for CS_TNC and CCS_VNC and agreement evaluation with Bland-Altman-Plots were performed.Results The average effective doses in TNC, CCTA and total group were 0.69, 6.47 and 7.16 mSv, respectively. The effective dose was reduced by 10.6% and the scan time was reduced by 39% while using VNC images. There were significant differences among the CS_TNC and CS_VNC of LAD, LCx, RCA and Total (t=6.75, 5.33, 4.99, 6.60, P < 0.05). Excellent correlations were observed between CS_VNC and CS_TNC (R2 values were 0.929, 0.896, 0.958, and 0.918; λ values were 2.18, 1.18, 2.15, and 2.07, respectively). There were no significant statistically difference among the CS_TNC, CCS_VNCAVG, and CCS_VNCLAD/RCA of the LAD and RCA (all P> 0.05). The difference was statistically significant among the CS_TNC, CCS_VNCAVG, and CCS_VNCLCx of the LCx (F=10.94, P < 0.05). The paired comparison were performed in groups and the differences were statistically significant between the CS_TNC versus CCS_VNCAVGand CCS_VNCAVG versus CCS_VNCLCx (t=3.31, 3.43, all P < 0.05). There was no significant statistically difference between the CCS_VNCLCx and CCS_VNCAVG(P > 0.05).Conclusions It was feasible to accurately evaluate the CS_VNC from spectral data in comparison to TNC imaging, and to reduce the patient radiation dose and acquisition time. |
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