| Han Lin,Zhang Bingjie,Wang Ping,Li Jie,Du Shasha,Mao Yuxuan,Zhao Fengling,Liu Yulong,Lyu Yumin.Biodosimetry estimation of a case of large area back skin injury caused by accidental irradiation in interventional procedure[J].Chinese Journal of Radiological Medicine and Protection,2021,41(12):886-891 |
| Biodosimetry estimation of a case of large area back skin injury caused by accidental irradiation in interventional procedure |
| Received:July 12, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.12.002 |
| KeyWords:Interventional procedure Radiation skin injury Unstable chromosomal aberration Biological dose estimation Dose reconstruction |
| FundProject:河南省科技攻关计划项目（142102310086）；河南省医学科技攻关计划项目（LHGJ20190815） |
| Author Name | Affiliation | E-mail | | Han Lin | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Zhang Bingjie | Prevention and Treatment Center for Occupational Disease of Xinxiang City, Xinxiang 453003, China | | | Wang Ping | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Li Jie | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Du Shasha | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Mao Yuxuan | Prevention and Treatment Center for Occupational Disease of Xinxiang City, Xinxiang 453003, China | | | Zhao Fengling | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | | | Liu Yulong | Second Affiliated Hospital of Soochou University, Suzhou 215004, China | | | Lyu Yumin | Henan Institute of Occupational Medicine, Henan Key Laboratory of Medicine on Radiobiology and Epidemiology, Zhengzhou 450052, China | lym636160@sina.com |
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| Abstract:: |
| Objective To evaluate biological dose and retrospective biodosimetry of a case of large area back skin injury caused by suspected interventional procedure. Methods Peripheral blood from the patient was collected at about 7 months after interventional procedure, and the chromosomal aberrations in peripheral blood cells were analyzed to evaluate the retrospective biodosimetry using the correction factor of dose estimation, Dolphin's model and Qdr method, respectively. Results Based on the amounts of semi-automated dic and manually detected dic plus ring, the whole-body average absorbed dose of the victim was estimated to be 0.68-0.95 Gy by four different dose response curves. Over dispersion of dic or dic plus ring was also detected, and the efficiency of dose assessment was obviously increased using dic semi-automatic detection. Based on three different retrospective biodosimetry models, the estimated average absorbed dose was further corrected to be between 1.80-2.86 Gy, which was consistent with clinical diagnosis of degree Ⅳ radiation skin injury. Conclusions A case of suspected radiation skin injury was confirmed by chromosomal aberration analysis and it's biodosimetry was reconstructed, suggesting that the unstable chromosomal aberration analysis may be applicable to assess the retrospective biodosimetry of non-uniform local radiation exposure. |
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