| Li Zhenkai,Wang Ping,Cheng Yuanbo,Li Jie,Yu Qi,Zhu Yonghang,Wang Zhaonan,Zhang Qiao,Lyu Yumin.Influencing factors of serum insulin-like growth factor binding protein-3 level in radiological workers in medical institutions[J].Chinese Journal of Radiological Medicine and Protection,2021,41(10):721-725 |
| Influencing factors of serum insulin-like growth factor binding protein-3 level in radiological workers in medical institutions |
| Received:March 26, 2021 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.10.001 |
| KeyWords:Ionizing radiation Radiation workers Serum Insulin-like growth factor binding protein-3 Biomarker |
| FundProject:河南省重点科技攻关项目（142102310086）；河南省医学科技攻关计划项目（LHGJ20190815） |
| Author Name | Affiliation | E-mail | | Li Zhenkai | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Wang Ping | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Cheng Yuanbo | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Li Jie | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Yu Qi | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Zhu Yonghang | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Wang Zhaonan | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Zhang Qiao | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Lyu Yumin | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | lym636160@sina.com |
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| Abstract:: |
| Objective To investigate the influence of low-dose ionizing radiation on the expression level of serum insulin-like growth factor binding protein-3 (IGFBP-3) in radiation workers in hospitals. Methods 183 radiation workers were randomly selected and grouped by work type including interventional radiology (n=37), nuclear medicine (n=43), radiotherapy (n=48), and diagnostic radiology (n=55). The content of IGFBP-3 in the serum of radiation workers was detected by ELISA assay. Results It was observed that the expression level of serum IGFBP-3 in the four groups had significant differences (F=6.056, P<0.05), and the content of serum IGFBP-3 in the interventional radiology group was significantly higher than that of nuclear medicine, radiotherapy, and diagnostic radiology groups (t= 2.815, 3.611, 3.936, P<0.05). The concentration of IGFBP-3 in the serum of radiation workers among different annual effective dose groups was statistically different (F=8.380, P<0.05), which gradually increased with the increase of annual effective dose and length of service (rs=0.202, 0.151,P<0.05). Conclusions The expression level of serum IGFBP-3 has the potential to be used as a biomarker to reflect the cumulative exposure of long-term chronic low-dose ionizing radiation. |
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