| Xu Di,Zhang Yucai,Zhou Qiyi,et al.Boron neutron capture therapy of cancers: principles and recent research progress[J].Chinese Journal of Radiological Medicine and Protection,2021,41(1):74-77 |
| Boron neutron capture therapy of cancers: principles and recent research progress |
| Received:October 15, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2021.01.015 |
| KeyWords:Boron neutron capture therapy Neutron sources Boron delivery agents Cancer |
| FundProject:国家自然科学基金（31600805）；江苏省自然科学基金（BK20160329） |
| Author Name | Affiliation | E-mail | | Xu Di | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | | | Zhang Yucai | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | | | Zhou Qiyi | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | | | Zhao Li | School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China | lizhao@suda.edu.cn |
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| Abstract:: |
| Boron neutron capture therapy (BNCT) is a new method for the precise treatment of cancers.By this method, cancer cells can be selectively killed by α particles and recoiling 7Li nuclei generated by the nuclear fission reaction occurring when the 10B isotope atoms in cancer cells capture thermal neutrons.The key to a successful BNCT is to deliver sufficient 10B into the cancer cells.The purpose of this review is to introduce the principles of BNCT and review recent progress in the development of neutron sources and boron delivery agents, as well as the result of BNCT clinical trials. |
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