| Ma Liping,Liu Qingjie,Tian Mei,et al.Research progress of p62/SQSTM1-mediated premature cellular senescence induced by radiation[J].Chinese Journal of Radiological Medicine and Protection,2020,40(12):968-972 |
| Research progress of p62/SQSTM1-mediated premature cellular senescence induced by radiation |
| Received:May 01, 2020 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.12.013 |
| KeyWords:Ionizing radiation Premature cellular senescence Signaling pathway p62/SQSTM1 |
| FundProject:国家自然科学基金（31570852，31570854）；北京市自然科学基金（7162137，7202139） |
| Author Name | Affiliation | E-mail | | Ma Liping | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Qingjie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gao Ling | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | gaolingxinxin@126.com |
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| Abstract:: |
| Premature cellular senescence refers to the decrease of proliferation and physiological function stimulated by non-telomere signals, promoting early aging. Ionizing radiation can cause DNA damage and induce premature cellular senescence by permanently halting the cell cycle or starting SASP signal factor. The signaling pathways of ionizing radiation-induced premature cellular senescence are complex and may include p53, p16, p38MAPK and p62. This review summarized the research progress of radiation-induced premature cellular senescence mediated by p62/SQSTM1. |
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