| Su Ming,Yin Yong,Han Zhujun,Qiu Xiaoping,Qiu Qingtao,Gong Guanzhong.Quantitative analysis on the dynamic changes in heart beat cycle of radiomics characteristics in left ventricular myocardial CT[J].Chinese Journal of Radiological Medicine and Protection,2020,40(8):636-641 |
| Quantitative analysis on the dynamic changes in heart beat cycle of radiomics characteristics in left ventricular myocardial CT |
| Received:November 13, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.08.011 |
| KeyWords:Cardiac Cycle Myocardial function Assessment Radiomics |
| FundProject:山东省重点研发计划（2018GSF118048，2018GSF118006） |
| Author Name | Affiliation | E-mail | | Su Ming | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Yin Yong | Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Han Zhujun | Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Qiu Xiaoping | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Qiu Qingtao | Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Gong Guanzhong | Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | gongguanzhong@yeah.net |
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| Abstract:: |
| Objective To provide a feasible method for the evaluation of cardiac function based on cardiac gated 4DCT, the radiomics technology combined with enhanced ECG gated 4DCT images were used to quantitatively analyze the changes of left ventricular CT radiomics characteristics in cardiac cycle. Methods The enhanced ECG 4DCT images of 14 patients were reconstructed at intervals of 5% of cardiac cycle. The left ventricular muscle (LVM) and the contrast agent well filled area of left ventricular were delineated with a 13 mm diameter sphere (Cardiac Region of Interest, cardiac ROI) in a single phase. 3Dslicer software was used to extract 92 features of all the sketches, analyze the distribution of CT values on the cardiac ROI and LVM, and preliminarily screen the stable features based on the cardiac ROI (one-way ANOVA).The stable features were used to further screen LVM (one-way ANOVA) to get the difference features. Wilcoxon rank sum test was used to analyze the change of characteristics with heartbeat in the heartbeat cycle. Results In the heartbeat cycle the mean CT values of cardiac cavity ROI in cardiac cavity changed less than that in LVM, with the change rates of 9.23% and 17.88%, respectively. There were 36 stable features with no significant difference in cardiac cavity ROI (P>0.05). 20 of them were statistically significant (F=1.641-6.206, P<0.05), and the average change rate was 98.63%, such as median (-103.96%) and mean (123.67%) of the first order matrix, gray level non uniformity (99.81%) of GLDM matrix and other changes reached more than 99%. The differences between the maximum and minimum values in different cardiac cycles were statistically significant (Z=-3.921--3.173, P<0.05). Conclusions With the combination of radiomics and enhanced ECG 4DCT image, the microscopic changes of CT image features in the cardiac cycle can be amplifed. A new method for the assessment of left ventricular function changes was provided. The features such as median, mean may have more application potential. |
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