| Shi Jingzhen,Li Fengxiang,Li Jianbin,et al.Comparison of the gross target volume based on diagnostic PET/CT for primary esophageal cancer[J].Chinese Journal of Radiological Medicine and Protection,2020,40(4):290-295 |
| Comparison of the gross target volume based on diagnostic PET/CT for primary esophageal cancer |
| Received:November 11, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2020.04.008 |
| KeyWords:Thoracic esophageal cancer Gross target volume 18F-FDG PET/CT Three-dimensional computed tomography Deformable image registration |
| FundProject:国家自然科学基金（81773287）；国家重点研发计划项目（2016YFC0904700）；山东省自然科学基金（ZR2019PH115）；山东省重点研发计划项目（2016GSF201093） |
| Author Name | Affiliation | E-mail | | Shi Jingzhen | School of Medicine, Shandong University, Jinan 250012, China | | | Li Fengxiang | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong Universitiy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Li Jianbin | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong Universitiy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | lijianbin@msn.com | | Zhang Yingjie | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong Universitiy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Guo Yanluan | Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Wang Wei | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong Universitiy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Wang Jinzhi | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong Universitiy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | |
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| Abstract:: |
| Objective To compare positional and volumetric differences between the gross target volumes (GTV) delineated on three-dimensional CT (3D-CT) referencing 18F-FDG PET/CT and the GTV on the deformed image derived from 3D-CT and 18F-FDG PET/CT for primary thoracic esophageal cancer (EC). Methods Seventy-two patients underwent chemoradiotherapy were enrolled. All the patients sequentially underwent 18F-FDG PET/CT scans for diagnosis and 3D-CT scans for simulation. The GTV3D was delineated on 3D-CT without referencing 18F-FDG PET/CT. The GTVPET-ref was delineated on 3D-CT referencing 18F-FDG PET/CT. The GTVPET-regwas delineated on the deformed image derived from 3D-CT and 18F-FDG PET/CT by MIM deformable registration software. The differences in position, volume, length, conformity index (CI), and degree of inclusion (DI) of target volumes were compared, respectively. Results The median volume of GTV3D, GTVPET-ref, GTVPET-reg were 44.90, 40.36 and 41.15 cm3, respectively. There was no statistical difference between the volumes of any two targets. The mean lengths of GTV3D, GTVPET-ref, GTVPET-reg were 8.54, 9.29 and 8.38 cm, respectively. The length of GTVPET-ref was longer than that of GTV3D(t=2.134,P<0.05).The median DIs of GTVPET-ref, GTVPET-regin GTV3D were 0.86, 0.82(Z=-2.741,P<0.05), and that of GTV3D in GTVPET-ref, GTVPET-reg were 0.87, 0.84 (Z=-1.429,P<0.05). The median CIs of GTV3D in GTVPET-ref and GTVPET-reg were 0.72,0.68 (Z=2.756,P<0.05), and the difference was significant. The CIs of GTV3D and GTVPET-ref, GTV3D and GTVPET-reg, GTVPET-ref and GTVPET-reg had significant negative correlation with the distance of target centers. Conclusions There was no significant difference between GTV contoured on three-dimensional CT (3D-CT) referencing 18F-FDG PET/CT and the GTV on the deformed image derived from 3D-CT and 18F-FDG PET/CT either in volume size or in spatial position. Therefore, it is recommended that radiation oncologists can refer to the recent diagnostic PET/CT when delineating the gross target volume for primary thoracic esophageal cancer. |
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