| Gao Mengdan,Ye Xuxue,Lu Lihuai,Wang Qiongqiong,Zhou Qingyu,Gao Ya,Li Yifei,Xie Congying.Research progress of S1PR1 in tumor metastasis-promoting and radiotherapy resistance[J].Chinese Journal of Radiological Medicine and Protection,2019,39(8):599-602 |
| Research progress of S1PR1 in tumor metastasis-promoting and radiotherapy resistance |
| Received:April 02, 2019 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.08.007 |
| KeyWords:S1PR1 Metastasis Radiotherapy resistance |
| FundProject: |
| Author Name | Affiliation | E-mail | | Gao Mengdan | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Ye Xuxue | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Lu Lihuai | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Wang Qiongqiong | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Zhou Qingyu | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Gao Ya | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Li Yifei | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | | | Xie Congying | Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China | wzxiecongying@163.com |
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| Abstract:: |
| Distant metastasis is one of the main obstacles to cancer treatment. Overexpression of S1PR1 in malignant tumors enhances cell invasion and migration activity, mediates EMT and induces lymphangiogenesis and angiogenesis via activation of its downstream signaling pathways,eventually results in the occurrence of tumor metastasis. S1PR1 is also closely related to generation of acquired radiotherapy resistance. This article discusses the roles of S1PR1 in tumor metastasis and radiotherapy resistance. |
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