| Li Kexin,Ju Yongjian,Cao Liyuan,et al.The dosimetric effect of inconsistency of bladder filling states between CT simulation and IMRT treatment for prostate cancer patients[J].Chinese Journal of Radiological Medicine and Protection,2019,39(3):192-196 |
| The dosimetric effect of inconsistency of bladder filling states between CT simulation and IMRT treatment for prostate cancer patients |
| Received:May 31, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2019.03.006 |
| KeyWords:Bladder volume Prostate cancer CBCT Dosimetric parameters |
| FundProject:国家自然科学基金资助项目（10705016）；江苏省六大人才高峰课题（2014-WSN-075） |
| Author Name | Affiliation | E-mail | | Li Kexin | Department of Radiation Oncology, The First People's Hospital of Nantong City, Nantong 226001, China | | | Ju Yongjian | Department of Radiation Oncology, The First People's Hospital of Nantong City, Nantong 226001, China | juyongjian@aliyun.com | | Cao Liyuan | Department of Radiation Oncology, The First People's Hospital of Nantong City, Nantong 226001, China | | | Zhang Liang | Department of Radiation Oncology, The First People's Hospital of Nantong City, Nantong 226001, China | | | Gao Xuan | Department of Radiation Oncology, The First People's Hospital of Nantong City, Nantong 226001, China | |
|
| Hits: 3845 |
| Download times: 1906 |
| Abstract:: |
| Objective To analyze the dosimetric effect of inconsistent bladder filling states between the CT simulation and treatment for prostate cancer patients undergoing intensity-modulated radiotherapy (IMRT). Methods A total of 42 prostate cancer patients treated with IMRT were selected. After vacuum pad immobilization and simulation CT scan, the delineation of targets and organs-at-risk (OARs), treatment planning and dose calculation were performed on treatment planning system (TPS). The cone-beam-CT (CBCT) acquired before the first treatment was registered to planning CT, on which the target contours were duplicated and OARs were delineated. After dose recalculation on the CBCT using the same plan, the dosimetric differences on the CT and CBCT were compared, including mean dose of the planning target volume (PTV), homogeneity index (HI), conformity index (CI); the mean dose, V30, V40, V50, V60, and V65 of bladder and rectum respectively. Results Relative to the bladder volumes at simulation, the patients were divided into two groups with larger (15 cases) or smaller (27 cases) bladders at the first treatment. Comparing the parameters obtained from simulation CT with that from CBCT, the differences of the following parameters were of statistical significance:the bladder volume, PTV HI, PTV CI in both groups (t=6.838, -4.372, -3.553, -3.462, 6.380, 5.037, P<0.05), the bladder V30, V40, V50, V60, V65 (t=-5.004, -4.092, -3.124, -2.707, -2.489, P <0.05) and rectal V40, V50, V60, V65, mean dose in the group with smaller bladders (t=-2.946, -2.643, -2.426, -3.127, -2.530, P <0.05), and the bladder V30, V40, V50 and mean dose in group with larger bladders (t=5.107, 4.204, 3.777, 4.155, P<0.05). Conclusions For prostate cancer patients undergoing IMRT, the inconsistent bladder filling states between the planning and treatment will cause disimetric differences of targets and OARs. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
