| Luo Hui,Qiao Lili,Li Yonghan,Zhang Dandan,Jia Xuechao,Nie Wenna,Zheng Xiaoli,Sun Yanan,Fan Chengcheng,Ge Hong.Research progresses of the roles of disulfiram in anticancer activity and radiobiology[J].Chinese Journal of Radiological Medicine and Protection,2018,38(8):631-634 |
| Research progresses of the roles of disulfiram in anticancer activity and radiobiology |
| Received:January 12, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.08.014 |
| KeyWords:Disulfiram Cancer Clinical studies Molecular mechanism Radiosensitivity |
| FundProject:国家自然科学基金（81372436） |
| Author Name | Affiliation | E-mail | | Luo Hui | Division of Graduate, The Second Clinical Medical School and the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China | | | Qiao Lili | Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China | | | Li Yonghan | China-US Hormel Cancer Institute, Zhengzhou 450003, China | | | Zhang Dandan | China-US Hormel Cancer Institute, Zhengzhou 450003, China | | | Jia Xuechao | China-US Hormel Cancer Institute, Zhengzhou 450003, China | | | Nie Wenna | China-US Hormel Cancer Institute, Zhengzhou 450003, China | | | Zheng Xiaoli | Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Sun Yanan | Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Fan Chengcheng | Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Ge Hong | Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | gehong616@126.com |
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| Abstract:: |
| Disulfiram (DSF) has been widely used in clinical treatment of alcoholism. To date, in vivo and in vitro experiments have demonstrated that DSF has strong anti-cancer activity and could improve patient's survival, and the underlying mechanism has been elaborated. In addition, it was reported that, during radiotherapy, DSF could protect normal tissue and cells meanwhile enhance the radiosensitivity of tumor cells by forming complexes with copper ions, suppressing cancer stem cells and inhibiting ubiquitin-proteasome system activity in cancer cells. This review summarizes the completed and ongoing clinical trials of disulfiram, and its anti-tumor mechanisms and advances in radiation biology. |
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