| Gao Yu,Wang Ping,Tian Chongbin,et al.Serum 8-hydroxy-2-deoxyguanosine level of radiation workers in hospitals[J].Chinese Journal of Radiological Medicine and Protection,2018,38(4):253-257 |
| Serum 8-hydroxy-2-deoxyguanosine level of radiation workers in hospitals |
| Received:January 24, 2018 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.04.003 |
| KeyWords:Ionizing radiation Radiation workers Interventional radiology 8-hydroxy-2-deoxyguanosine |
| FundProject:河南省重点科技攻关项目（142102310086）；国家重点临床专科建设项目（2011-17） |
| Author Name | Affiliation | E-mail | | Gao Yu | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Wang Ping | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Tian Chongbin | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Han Lin | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Li Jie | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Wang Zhaonan | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | | | Wu Yanyan | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Zhao Fengling | Henan Institute of Occupational Medicine, Zhengzhou 450052, China | | | Lyu Yumin | College of Public Health, Zhengzhou University, Zhengzhou 450001, China | lym636160@sina.com |
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| Abstract:: |
| Objective To explore the influence of long-term low-dose ionizing radiation on 8-hydroxy-2-deoxyguanosine(8-OHdG)level in the serum of radiation workers in hospitals. Methods 307 age-and sex-matched hospital radiation workers were recruited by stratified random sampling method. After deleting the subjects without dosage information,230 individuals were divided into four groups according to their job title[including diagnostic radiology(n=75), radiotherapy(n=60), nuclear medicine(n=41)and interventional radiology(n=54)]. Serum 8-OHdG level was measured by ELISA assay. Results According to the statistical analysis, there was significant difference in the serum 8-OHdG level among four groups (F=9.071, P < 0.05), and the content of serum 8-OHdG was significantly higher in the interventional radiology group than that in the groups of diagnostic radiology, radiotherapy and nuclear medicine (t=-4.473, -3.011, -2.189, P < 0.05). There were significant differences in serum 8-OHdG level among different dose groups and working period groups(F=7.659, 3.058, P < 0.05). The serum 8-OHdG levels significantly increased along with exposure dose and working period(r=0.300, 0.142, P<0.05).Conclusions Serum 8-OHdG may be a potential biomarker of oxidative DNA damage in radiation workers exposed to low-dose ionizing radiation. |
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