| Niu Xuena,Zhao Hanxi,Zhu Wanqi,Xing Ligang.Research progresses of green tea extract epigallocatechin-3-gallate on preventing and treating radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2018,38(1):69-72 |
| Research progresses of green tea extract epigallocatechin-3-gallate on preventing and treating radiation injury |
| Received:July 04, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2018.01.015 |
| KeyWords:Radiation injury Epigallocatechin-3-gallate Protection |
| FundProject:山东省自然科学基金（ZR2016HM35） |
| Author Name | Affiliation | E-mail | | Niu Xuena | School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250022, China | | | Zhao Hanxi | Department of Radiotherapy 10 Ward, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Zhu Wanqi | Department of Radiotherapy 10 Ward, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Xing Ligang | Department of Radiotherapy 10 Ward, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | xinglg@medmail.com |
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| Abstract:: |
| Radiotherapy is one of the important cancer therapy methods that can lead to tissue damage including radiation lung injury, radiation esophageal injury,radiation skin damage and abnormal changes in hemopoietic system and immune system. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. It has been demonstrated that EGCG has biological effects of anti-inflammatory, antioxidant, anti-apoptosis and regulating immunity. Recently some studies of cell and animal models suggest that EGCG has radioprotective effect, but few clinical research was reported. In this review, the studies about EGCG in preventing and treating radiation injury were summarized from anti-radiation mechanism in order to enhance the understanding of the potential clinical application of EGCG. |
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