| Zhang Yongxia,Yuan Xiangkun,Shi Fumin,et al.A dosimetric analysis of combined intracavitary/interstitial brachytherapy for locally advanced cervical cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(12):919-923 |
| A dosimetric analysis of combined intracavitary/interstitial brachytherapy for locally advanced cervical cancer |
| Received:April 11, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.12.008 |
| KeyWords:Cervical cancer Brachytherapy Intracavitary Interstitial interpolation Dosimetry |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhang Yongxia | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Yuan Xiangkun | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | yuanxiangkun@126.com | | Shi Fumin | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Hu Jianwei | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Gao Lei | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Miao Junjun | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Zuo Xiaona | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | | | Xie yuwei | Department of Radiotherapy and Chemotherapy, Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou 061000, China | |
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| Abstract:: |
| Objective To compare the dosimetric differences between intracavitary brachytherapy in combination with interstitial brachytherapy or not for locally advanced cervical cancer. Methods From May 2016 to March 2017, 35 patients with locally advanced cervical cancer treated with combined external beams and intracavitary/interstitial brachytherapy were selected in this study. The prescription of intensity-modulated radiation therapy was:46.8-50.4 Gy/26-28 fractions, 1.8 Gy/fraction. The prescription for combined intracavitary/interstitial brachytherapy was 7 Gy/fraction×4, once per week. Each patient was first implanted with a three tube applicator for brachytherapy, and the CT images were acquired for treatment planning. The three tube applicator was removed before a uterine tube and needles were implanted, thereafter planning images were acquired again. Dose to the targets and organs at risk were evaluated respectively for the two groups. Results A total of 212 brachytherapy plans were developed, including 106 intracavitary and 106 endoluminal combined interstitial plans. The target dose in endoluminal combined interstitial brachytherapy was significantly higher than that of intracavitary treatment alone, where D90 of the high-risk clinical target volume (CTV) and moderate CTV were both significantly increased (t=-6.01, -2.73, P<0.05). The D2 cm3 of the bladder, rectum and sigmoid colon were significantly reduced (t=3.07, 4.52, 2.91, P<0.05). Conclusions The application of the endoluminal combined interstitial brachytherapy for locally advanced cervical cancer can significantly increase the target dose, and reduce the dose to organs at risk such as the bladder, rectum and sigmoid colon. |
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