| Zhang Guifang,Lu Jie,Ma Changsheng,Sun Tao,Han Dali,Yin Yong.Application of liner-accelerator two-degrade collimator in the treatment of breast cancer after radical mastectomy with intensity-modulated radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2017,37(8):594-598 |
| Application of liner-accelerator two-degrade collimator in the treatment of breast cancer after radical mastectomy with intensity-modulated radiotherapy |
| Received:January 26, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.08.006 |
| KeyWords:Breast cancer Radical mastectomy IMRT Two-degrade collimator |
| FundProject:国家自然科学基金（81472811）；山东省医药卫生科技发展计划（2016WS0553）；山东省科技发展计划（2015GSF118017） |
| Author Name | Affiliation | E-mail | | Zhang Guifang | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Lu Jie | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Ma Changsheng | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Sun Tao | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Han Dali | Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | | | Yin Yong | Department of Radiation Physics, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, China | yongyinsd@163.com |
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| Abstract:: |
| Objective To evaluate the dosimetric impact of the fixed position of two-degrade collimator in the treatment of breast cancer after radical mastectomy using intensity-modulated radiotherapy (IMRT) technique. Methods A total of ten patients with breast cancer were treated with radical mastectomy and radiotherapy sequaciously involving the supraclavicular region and the chest wall. Two different IMRT treatment plans were designed for each patient:0°, 40° and two tangential field. There was no restriction on the position of two-degrade collimator(IMRT-1)(P>0.05). The beam angles and the parameters were as same as IMRT-1, but fixed the position of the two-degrade collimator of 0° and 40° at the inferior border of the supraclavicular(IMRT-2). The dose distribution of target volume and normal tissues, conformal index (CI), and heterogeneous index (HI) were estimated with the dose volume histogram (DVH) for the two intensity modulated modes. Results The CI were 0.79 and 0.73 (Z=-2.316, P<0.05), and the HI of the IMRT-2 plans was not different from IMRT-1(P>0.05). Considering the dose volumes of the ipsilateral lung in two plans, the values of V5, V10, Dmean of IMRT-2 were significantly less than those of IMRT-1(Z=-2.805, -2.812, -2.521, P<0.05). Meanwhile, the Dmean of the contralateral lung, Dmean of heart and Dmean of the contralateral breast from the IMRT-2 were all lower than those of IMRT-1(Z=-2.666, -2.701, -2.310, P<0.05). There was no significant difference in the values of V20, V30 of the ipsilateral lung, V30 of heart and between IMRT-1 and IMRT-2(P>0.05). Conclusions Compared with IMRT-1, IMRT-2 with fixed position of the two-degrade collimator could significantly reduce the low dose region of the lung and heart. It may be used as an effective alternative for breast cancer after radical mastectomy irradiation. |
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