| Shao Shuai,Tian Mei,Liu Jianxiang,Gou Qiao,Qi Xuesong,Wang Chunyan,Qu Gonglin,Li Chen,Su Xu.Protective effects of ferulic acid on mice bone marrow hematopoietic damage induced by irradiation[J].Chinese Journal of Radiological Medicine and Protection,2017,37(8):570-575 |
| Protective effects of ferulic acid on mice bone marrow hematopoietic damage induced by irradiation |
| Received:March 10, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.08.002 |
| KeyWords:Ferulic acid Radiation protection Bone marrow hematopoiesis Thrombomodulin High mobility group box-1 protein |
| FundProject:国家自然科学基金（81303316） |
| Author Name | Affiliation | E-mail | | Shao Shuai | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tian Mei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Gou Qiao | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Qi Xuesong | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Wang Chunyan | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Qu Gonglin | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Li Chen | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Su Xu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | suxu@nirp.cn |
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| Abstract:: |
| Objective To observe the effect and the mechanisms of ferulic acid on radiation-induced damage of mice peripheral blood and bone marrow hematopoietic function. Methods Ninety-six mice were randomly divided into sham irradiation group, irradiation group, positive drug group and 10, 30, 90 mg ·kg-1 ·d-1 ferulic acid group, 16 mice per group. Mice were exposed to 3.5 Gy γ-rays 24 h after first drug taken. Then, mice were given drugs for 7 d after irradiation. White blood cells in peripheral blood of 10 mice per group were counted 2 d before irradiation and 3, 7, 10, 15 and 22 days after irradiation. The bone marrow of the other six mice was taken to detect the micronuclei frequency of polychromatic erythrocyte, the hematopoietic progenitor cell colony formation capacity, Thbd and HMGB1 protein expressions in mice bone marrow on the seventh day after irradiation. Results Compared with the irradiation alone group, the treatment of mice with ferulic acid 90 mg ·kg-1 ·d-1 increased the number of white blood cells in peripheral blood at 3, 10, 15 and 22 d after irradiation (t=2.267,2.399,1.945,2.828,P<0.05). Treatment with mice with ferulic acid 90 mg ·kg-1 ·d-1 decreased the micronuclei rate of erythrocytes in irradiated bone marrow (t=4.013,P<0.05), increased the clone numbers of CFU-E, BFU-E and CFU-GM of hematopoietic progenitor cells (t=2.366,2.953,3.115,P<0.05), improved the relative expression of the Thbd protein in bone marrow and the HMGB1 protein in nuclear (t=17.75,23.39,P<0.01). Conclusions Ferulilc acid could protect the bone marrow hematopoietic of mice exposed to irradiation by regulating the expressions of Thbd and HMGB1 protein, and then accelerate the peripheral cells recovery. |
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