| Cao Qiang,Huo Bin,Huo Xiaodong,Wang Jinhuan,Wang Lei,Zang Li,Hou Dingkun,Wang Haitao,Wang Junjie,Chai Shude.Dosimetric study of 3D-printing coplanar template combined with CT-guided 125Ⅰ seed implantation for treating non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2017,37(7):528-532 |
| Dosimetric study of 3D-printing coplanar template combined with CT-guided 125Ⅰ seed implantation for treating non-small cell lung cancer |
| Received:April 05, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.07.011 |
| KeyWords:3D-printing Coplanar template Free hand 125Ⅰ seed implantation Non small cell lung cancer |
| FundProject:国家自然科学基金（81572543）；天津市自然科学基金（15JCYBJC28400） |
| Author Name | Affiliation | E-mail | | Cao Qiang | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Bin | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Huo Xiaodong | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Jinhuan | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Lei | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Zang Li | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Hou Dingkun | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Wang Haitao | Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | peterrock2000@126.com | | Wang Junjie | Department of Thoracic Surgery, The Second Hospital of Tianjin Medical University, Tianjin 300211, China | | | Chai Shude | Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China | |
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| Abstract:: |
| Objective To explore the safety, effectivity and dosimetric continence of 3D-printing coplanar template(3D-PCT)combined with CT-guided 125Ⅰ seed implantation in the treatment of non-small cell lung cancer(NSCLC). Methods From May 2014 to November 2016, a total of 20 NSCLC patients who were suitable for 125Ⅰ seed implantation were recruited in this study. Of all the patients, 10 received 125Ⅰ seed implantation treatment by CT-guided combined with 3D-PCT (3D group), and the rest, by free-hand puncture combined with CT-guided 125Ⅰ seed implantation (free-hand group). During two days before the surgery, the patients received the CT scan. Then the digital imaging and communications in medicine(DICOM) was collected to input to the Brachytherapy Treatment Planning System(BTPS). The dose parameters including D90, D100,V100, V150, conformal index(CI), external index(EI),and homogneneity index(HI) were compared between pre-operation and post-operation. Pair t-test and single sample t-test were performed. Results V150 in 3D group between preoperation and postoperation showed statistically significant difference(t=-2.916, P< 0.05), and there was no significant difference in the rest parameters(P> 0.05). However, the number of seeds, V100, EI, HI in free-hand group between preoperation and postoperation showed statistically significant difference(t=-2.516, 2.492, 4.725, 7.258, P< 0.05), and there was no significant difference in the rest parameters(P> 0.05). Comparison of indicuted that there was significant difference in V100, V150, CI, EI, HI and dose error rate between the 3D group and the free-hand group with single sample t test,the result showed V100, CI, EI, HI between two groups(t=2.598, 2.278, 4.637, 4.616, -4.785, P< 0.05),and there was no significant difference in V150 (P> 0.05). Conclusions CT-guided 125Ⅰ seed implantation brachytherapy combined with 3D-PCT for treatment of NSCLC safe is feasible, and dose controllable, and there is a certain advantage in the spatial distribution of seed compared with free-hand puncture. |
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