| Yin Liangliang,Tian Qing,Huang Wei,et al.ICP-MS method for the determination of uranium concentration and 235U/238U ratio in urine and its uncertainty evaluation[J].Chinese Journal of Radiological Medicine and Protection,2017,37(5):376-380 |
| ICP-MS method for the determination of uranium concentration and 235U/238U ratio in urine and its uncertainty evaluation |
| Received:January 15, 2017 |
| DOI：10.3760/cma.j.issn.0254-5098.2017.05.011 |
| KeyWords:Uranium 235U/238U ratio Inductively coupled plasma mass spectrometry (ICP-MS) Urine Uncertainty |
| FundProject:国家科技基础性工作专项（2014YF211000）；卫生行业科研项目（201002009） |
| Author Name | Affiliation | E-mail | | Yin Liangliang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086, China | | | Tian Qing | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086, China | | | Huang Wei | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086, China | | | Shao Xianzhang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086, China | | | Ji Yanqin | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086, China | jiyanqin@nirp.cn |
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| Abstract:: |
| Objective To establish a method of analyzing total uranium and 235U/238U ratio in urine using inductively coupled plasma mass spectrometry (ICP-MS) and uncertainty assessment.Methods Urine sample was digested with HNO3 and H2O2, and total uranium was determined using ICP-MS method directly. The digested urine sample was separated to concentrate uranium with tributyl phosphate (TBP) column, and 235U/238U ratio was analyzed using ICP-MS. The uncertainty was evaluated through sample pre-treatment, measurement and standard curve calculation. Results The recovery of total uranium in urine was 98.4%-102.4%, detection limit was 0.002 μg/L. The relative expanded uncertainty of total uranium concentration in urine was 0.26 (k=2). 235U/238U ratio was 0.001 1 (k=2). Conclusions This study offers a low detection limit, good recovery and precision method for rapid determination of total uranium and 235U/238U ratio in urine samples. It is potential used for both in occupational exposure assessment and nuclear emergency situation. The uncertainty evaluation of total uranium and 235U/238U ratio in urine are reliable. |
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