| Zhu Yuequan,Xiong Kai,Wen Jie,Wang Junjie,Xue Lixiang.The relationship between microRNAs and colorectal cancer radiosensitivity and underlying mechanism[J].Chinese Journal of Radiological Medicine and Protection,2016,36(10):780-784 |
| The relationship between microRNAs and colorectal cancer radiosensitivity and underlying mechanism |
| Received:May 03, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.10.014 |
| KeyWords:microRNAs Colorectal cancer Cancer radiosensitivity |
| FundProject:国家自然科学基金（81541142，81402519，81672091）；首都临床特色应用研究基金（Z151100004015171） |
| Author Name | Affiliation | E-mail | | Zhu Yuequan | Department of Biochemistry and Molecular Biology, School of Basis Medicine, Peking University, Beijing 100191, China | | | Xiong Kai | Medical Research Center, Peking University Third Hospital, Department of Radiotherapy, Peking University Third Hospital, Beijing 100191, China | | | Wen Jie | Medical Research Center, Peking University Third Hospital, Department of Radiotherapy, Peking University Third Hospital, Beijing 100191, China | | | Wang Junjie | Medical Research Center, Peking University Third Hospital, Department of Radiotherapy, Peking University Third Hospital, Beijing 100191, China | | | Xue Lixiang | Medical Research Center, Peking University Third Hospital, Department of Radiotherapy, Peking University Third Hospital, Beijing 100191, China | lixiangxue@hsc.pku.edu.cn |
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| Abstract:: |
| Colorectal cancer is currently the third most common cancer worldwide, and there are still half of the patients undergoing recurrence and metastasis after surgical treatment, so it is necessary for colorectal cancer patients to receive radiation therapy routinely. Due to the side effects brought by radiotherapy, it is of great importance to solve how to minimize the radiation dose in radiation therapy and improve radiation sensitivity. In recent years, people discovered that microRNAs can not only be involved in the origins of colorectal cancer and progress, but also play a increasingly important role in cancer radiosensitivity. MicroRNAs can regulate tumor radiosensitivity by influencing tumor microenvironment and function on target genes. DNA damage response caused by radiation includes the activation of ATM, histone modification and chromatin remodeling, cell cycle arrest, damage repair and apoptosis. microRNAs can regulate tumor radiosensitivity through above processes. This review focuses on the mechanism of microRNAs in affecting DNA damage repair and prospects the future of microRNAs in influencing the sensitivity of cancer radiotherapy in clinical application. |
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