| Su Yinping,Tan Guangxiang,Lei Shujie,Zou Jianming,Zhang Sufen,Liu Jianxiang,Li Xiaoliang,Sun Quanfu,Akiba Suminori.Preliminary research on relationship between long-term low dose radiation exposure and the carotid intima-media thickness of female residents in high background radiation area in Yangjiang, China[J].Chinese Journal of Radiological Medicine and Protection,2016,36(9):682-687 |
| Preliminary research on relationship between long-term low dose radiation exposure and the carotid intima-media thickness of female residents in high background radiation area in Yangjiang, China |
| Received:February 16, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.09.009 |
| KeyWords:Carotid intima-media thickness Long-term low dose radiation exposure High background radiation area Atherosclerosis |
| FundProject:中日合作阳江地区放射流行病研究（901004） |
| Author Name | Affiliation | E-mail | | Su Yinping | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Tan Guangxiang | Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300, China | | | Lei Shujie | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Zou Jianming | Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300, China | | | Zhang Sufen | Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300, China | | | Liu Jianxiang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Li Xiaoliang | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Sun Quanfu | Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | qfusun@nirp.cn | | Akiba Suminori | Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan | |
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| Abstract:: |
| Objective To explore the effect on cardiovascular and cerebrovascular diseases for people due to long-term low dose radiation exposure. Methods Four regions were selected from the high background radiation area (HBRA) in Yangjiang, featuring highest external γ radiation dose rate, and two regions from control area (CA) was chosen at the similar distance from downtown as four regions selected from the high background radiation area. Each of one hundred female residents aged more than 50 years old respectively selected from the HBRA in Yangjiang and in the CA. The carotid intima-media thickness (CIMT) was measured using ultrasonic examination. The peripheral venous was sampled to measure the levels of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol. Blood pressure, height and weight were also measured. Personal life and living history were collected through questionnaires. The estimation of personal lifetime accumulated radiation dose was based on γ-ray dose rate from indoor and outdoor and the age-related occupancy factor obtained from the previous studies. Results There were statistically significant differences of accumulated radiation dose and CIMT of residents between Yangjiang HBRA and CA[(161.2±38.6) mSv vs. (43.7±7.3) mSv, L (1.0±0.3) mm/R (1.0±0.2) mm vs. L&R (0.9±0.2) mm]. The average age was (65.2±10.4) years old for HBRA and (60.7±8.0) years old for CA,respectively. After adjusting confounding factors, including age, blood pressure, BMI and serum cholesterol, the increased cumulative radiation dose was shown to be a risk factor for thickening left CIMT (β=0.000 7,P<0.05). The left CIMT for different dose groups was 0.9, 1.0, 0.9 and 1.1 mm for <50, 50-100, 100-200, >200 mSv, respectively. Conclusions Long-term low dose radiation exposure may age the vascular, and increasing the risk of atherosclerosis. |
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