| Yang Lu,Zhang Yingjie,Li Guangjun,et al.Application of active breathing control (ABC) and four dimensional CT technology in stereotactic radiotherapy of lung tumor[J].Chinese Journal of Radiological Medicine and Protection,2016,36(9):667-671 |
| Application of active breathing control (ABC) and four dimensional CT technology in stereotactic radiotherapy of lung tumor |
| Received:March 08, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.09.006 |
| KeyWords:Active breathing control 4D-CT Stereotactic body radiation therapy Prescription dose Lung tumor |
| FundProject:四川省科技厅项目（2016JY0072） |
| Author Name | Affiliation | E-mail | | Yang Lu | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | | | Zhang Yingjie | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | | | Li Guangjun | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | | | Wang Dajiang | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | | | Liu Fubo | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | | | Bai Sen | Radiation Physics Technology Center, West China Hospital of Sichuan University, Chengdu 610041, China | baisen@scu.edu.cn |
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| Abstract:: |
| Objective To investigate the difference of lung and target volume and dosimetry characteristics features of deep inhalation breathing holding-active breathing control (ABC) and the four dimensional CT (4D-CT) free breathing in stereotactic body radiation therapy (SBRT) technology for patients with lung cancer. Methods 10 patients with pulmonary malignant tumor who were proposed SBRT treatment were selected, and received CT under free breath (FB-CT), 4D-CT scan under quiet respiration (4D-CT) and active breathing control CT scan (ABC-CT), respectively. With SBRT technology under the same condition designed four corresponding plans, FB-CT, ABC-CT, 4D-CT and 4D-CT0 which was the end inspiratory phase of 4D-CT respectively. The lung volume(V), PTV, V5, V20, mean lung dose(MLD) and normal tissue complication probability(NTCP) of four treatment programs were counted and compared. Results Compared with FB-CT, V, PTV, V5, V20, MLD and NTCP of ABC-CT were 51.48%, -65.34%, -42.64%, -56.62%, -40.22% and -98.53% (t=-7.14 to 6.16, P<0.05); PTV, V5, V20, MLD and NTCP of 4D-CT were -40.14%, -16.90%, -37.16%, -17.85% and -90.96% (t=0.54 to 3.22, P<0.05); PTV, V5, V20, MLD and NTCP of 4D-CT0 were -68.98%, -30.21%, -48.49%, -37.45% and -95.82% (t=1.32 to 5.46, P<0.05), respectively. Compared with FB-CT, the lung volume of 4D-CT and 4D-CT0 had no statistical difference (P>0.05). Conclusions ABC-CT methods have ideal clinical characteristics, with larger double lung volume, smaller artifacts of image, and higher target matching precision. ABC-CT methods reduce the dose of normal lung tissues significantly. |
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