| Wang Youyou,Liu Yulong,Bian Huahui,Chen Weibo,Li Yuan,Zheng Xu,Bao Mingyue,Guo Kailin.Changes in hematopoietic system of the patient exposed to “5.7” 192Ir source accident in Nanjing[J].Chinese Journal of Radiological Medicine and Protection,2016,36(5):345-349 |
| Changes in hematopoietic system of the patient exposed to “5.7” 192Ir source accident in Nanjing |
| Received:February 05, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.05.007 |
| KeyWords:192Ir Mild bone marrow form of acute radiation sickness Hematopoietic system Granulocyte colony stimulating factor Immune function |
| FundProject:江苏省临床医学科技专项(BL2014040);江苏省卫生计生委2014-2015年度预防医学科研项目(Y2015024);江苏省研究生培养创新工程项目(SJLX15-0580) |
| Author Name | Affiliation | E-mail | | Wang Youyou | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Liu Yulong | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | yulongliu2002@126.com | | Bian Huahui | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Chen Weibo | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Li Yuan | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Zheng Xu | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Bao Mingyue | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | | | Guo Kailin | Department of Nuclear Emergency Center, Second Affiliated Hospital of Soochow University, Suzhou 215004, China | |
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| Abstract:: |
| Objective To observe and study the hematopoietic system injury to the patient exposed to 192Ir accident in Nanjing, in order to provide information and gain experience for medical treatments in nuclear and radiation accident emergencies.Methods Levels of white blood cell counts, lymphocyte counts, platelet counts and hemoglobin were determined by using blood cell analyzer. Bone marrow cells collected from bilateral iliac bone were used to access the changes in hematological system by bone marrow smear. Fusion gene or gene mutation caused by radiation were valuated by performing PCR-sequence-based typing(PCR-SBT). While blood T cells were analyzed by flow cytometry, immunoglobulin isotypes(IgA, IgG, IgM) and complement(C3, C4) levels in serum were measured by radioimmunoassay, in order to evaluate cellular and humoral immune function. Results The patient's marrow hematopoietic function showed mild disorder, and returned to normal after short-time treatment with G-CSF. The patient went into recovery phase about 40 days after exposure. The fusion genes were not detected in the mutant. Local infection resulted in the decline in lymphocyte counts and immune function. Conclusions Mild bone marrow form of acute radiation sickness induced light injury of hematopoietic system. The course stage was not apparent and hematopoietic function recovered soon. Immune suppression hadn't been caused. However, local infection can lead to the decrease of immune function. These results indicate that combined systemic and local treatment is crucial and essential to the patients after mild radiation. |
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