| Wang Jian,Wang Jianlin,Yu Jingping,et al.Clinical significance of continuous detection of VEGF in patients undergoing chemoradiotherapy for esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2016,36(4):278-282 |
| Clinical significance of continuous detection of VEGF in patients undergoing chemoradiotherapy for esophageal carcinoma |
| Received:January 04, 2016 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.04.009 |
| KeyWords:Esophageal carcinoma Chemoradiotherapy Vascular endothelial growth factor Prognosis |
| FundProject:江苏省卫生厅指导性科研项目(Z201220) |
| Author Name | Affiliation | E-mail | | Wang Jian | Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochou University, Changzhou 213003, China | | | Wang Jianlin | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Yu Jingping | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Sun Zhiqiang | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Sun Wei | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Nie Bin | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Ni Xinchu | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Sun Suping | Department of Radiotherapy, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | Wu Changping | Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochou University, Changzhou 213003, China | newwcp@163.com |
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| Abstract:: |
| Objective To observe the serum vascular endothelial growth factor(VEGF) change, in order to explore its correlation with the prognosis of patients with esophageal carcinoma treated with chemoradiotherapy. Methods Seventy patients with esophageal carcinoma who were treated with radiotherapy including fifty-three patients with concurrent chemotherapy were enrolled. Serum levels of VEGF were detected before, during(per week) and after radiotherapy by enzyme-linked immunoabsorbent assay (ELISA) and accordingly divided into three groups:rising group,stable group and declining group. Serum VEGF level of 30 healthy subjects served as the control. Results For all patients,the 1-year overall survival(OS) rate and 1-year progression free survival(PFS) rate were 55.7% and 51.4%,respectively. The median values of OS and PFS were 13.4 and 12.5 months, respectively. Thirteen patients were recurrent. Compared with baseline level, the VEGF decreased with significant differences during radiotherapy(F=6.806,P=0.001). The VEGF levels before,during(per week) and after radiotherapy were significantly higher than control group(t=2.165-3.896,P<0.05).There were statistical differences of 1-year OS rate and 1-year PFS rate among different VEGF changing groups(rising group,stable group and declining group)(χ2=6.811, 6.602,P<0.05). However, the local control(LC)rate of the above three groups showed no obvious difference(P>0.05). The baseline VEGF level(before radiotherapy) had no influence on OS,PFS or LC(r=-0.033,-0.056,0.090,P>0.05).VEGF rised mostly in the second,third week during radiotherapy or one week after radiotherapy for nineteen VEGF rising patients. Conclusions The serum VEGF change during chemoradiotherapy could predict the prognosis of patients with esophageal carcinoma. To monitor the VEGF levels in the second, third week during radiotherapy or one week after radiotherapy might have important value on individualized treatment for esophageal carcinoma patients. |
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