| Yue Dan,Yang Yongjing,Zhao Ling,et al.Clinical feasibility and accuracy of image guidance with kilovoltage cone-beam computed tomography in nasopharyngeal carcinoma intensity-modulated radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2016,36(3):211-215 |
| Clinical feasibility and accuracy of image guidance with kilovoltage cone-beam computed tomography in nasopharyngeal carcinoma intensity-modulated radiotherapy |
| Received:September 29, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.03.010 |
| KeyWords:Image guided radiation therapy (IGRT) Cone-beam computerized tomography (CBCT) Intensity-modulated radiotherapy (IMRT) Nasopharyngeal carcinoma (NPC) Setup errors |
| FundProject:吉林省科技发展计划项目(20090450) |
| Author Name | Affiliation | E-mail | | Yue Dan | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Yang Yongjing | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Zhao Ling | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Wu Hongfen | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Pu Mingwei | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Zhao Jihong | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Cao Ling | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Ma Rui | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Yang Jinlei | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | | | Liu Shixin | No. 1 Department of Radiation Oncology, Jilin Province Cancer Hospital, Changchun 130012, China | liushixin1964@sina.com |
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| Abstract:: |
| Objective To evaluate the set-up accuracy of intensity-modulated radiotherapy (IMRT) with the use of kilovoltage X-ray cone-beam computed tomography (kV-CBCT) and establish the proper planning target volume margins (MPTV) in nasopharyngeal carcinoma (NPC) patients.MethodsA total of 331 NPC patients were scheduled to undergo IMRT were retrospectively reenrolled in the study. An on-line correction protocol was adopted weekly since the implementation of kV-CBCT. The systematic (Σ) and random (σ) setup errors were calculated at different correction threshold levels. The MPTV were calculated according to the van Herk formula (2.5Σ+0.7σ). Results A total of 3 972 CBCT scans were analyzed. The pre-correction translational setup error and rotation setup error in x, y and z directions were (0.95±0.79), (1.04±0.66), (1.14±0.63) mm and 1.32°±0.99°, 1.45°±1.37°, 1.25°±1.35°. The post-correction were (0.56±0.44), (0.56±0.51), (0.42±0.63)mm and 0.78°±0.76°, 0.62°±0.85°, 0.75°±0.64°, respectively. Pre-correction MPTV were 2.93, 3.06 and 3.30 mm along the x, y and z axes; post-correction were 1.71, 1.76 and 1.49 mm. Conclusions kV-CBCT based online correction increased the accuracy of IMRT and reduced MPTV(<2.0 mm), by decreasing both the systematic and random errorsfor NPC. |
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