| Gong Xiuyun,Jin Feng,Wu Weili,et al.Study on delineation of gross tumor volume (GTV) of primary locally advanced nasopharyngeal carcinoma after induction chemotherapy[J].Chinese Journal of Radiological Medicine and Protection,2016,36(2):116-120 |
| Study on delineation of gross tumor volume (GTV) of primary locally advanced nasopharyngeal carcinoma after induction chemotherapy |
| Received:June 21, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.02.007 |
| KeyWords:Locally advanced nasopharyngeal carcinoma Induction chemotherapy MRI/CT fusion image Target volume delineation |
| FundProject:贵州省科技厅社发联合攻关项目(黔科合LG字[2012]044号) |
| Author Name | Affiliation | E-mail | | Gong Xiuyun | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Jin Feng | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | jinf8865@yeah.net | | Wu Weili | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Gan Jiaying | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Li Yuanyuan | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Long Jinhua | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Chen Xiaoxiao | Department of Head and Neck Oncology, Cancer Hospital of Guizhou Province, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China | | | Wang Limin | The First People's Hospital of Guiyang, Guiyang 550002, China | |
|
| Hits: 3894 |
| Download times: 2626 |
| Abstract:: |
| Objective To investigate the delineation primary lesions of the gross tumor volume (GTVnx) in locally advanced nasopharyngeal carcinoma (LANC). Methods During 2012—2013, 52 patients with LANC treated with two-three cycles of induction chemotherapy accepted CT simulation and MRI scans in the same treatment position. All the images of CT and T1W1 sequence of MRI were collected and transmitted to the treatment planning system. The gross target volume (GTVnx) was delineated through CT and MRI images. Meanwhile, metastatic lymph nodes, CTV1, CTV2 and organs at risk(OAR) were delineated through CT images alone. The images from MRI and CT were then fused as MRI/CT fusion images by radiotherapy system, and the same prescription dose and limitation dose of OAR were given as CT images. The changes of GTVnx, the radiation volume and dose, and dose coverage of normal organs from two different images were compared. Results The delineation volume in fused MRI/CT image[(43.14±28.40 cm3)] was larger than CT[(40.09±27.04) cm3] (t=3.791, P<0.001). And there was statistical difference between the two images in the GTV changes before and after IC, with MRI/CT (27.90±11.86) and CT[(30.64±11.86) cm3](t=3.948, P<0.001), respectively. The radiation volume in MRI/CT fusion image[(41.71±26.86) cm3] was larger than CT[(38.65±25.66) cm3] (t=4.098, P<0.001). But there were no statistical differences in target volume dose and dose coverage of normal organs between the two images. Conclusions The technique of MRI/CT fusion image can increase the radicalized GTV and may decrease the possibility of leaving out the target volume definition. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
