| Gu Jiabing,Zhu Jian,Wei Yumei,et al.The feasibility of prescription dose escalation for nasopharyngeal carcinoma cancer using helical tomotherapy[J].Chinese Journal of Radiological Medicine and Protection,2016,36(1):35-39 |
| The feasibility of prescription dose escalation for nasopharyngeal carcinoma cancer using helical tomotherapy |
| Received:May 28, 2015 |
| DOI：10.3760/cma.j.issn.0254-5098.2016.01.006 |
| KeyWords:Helical tomotherapy Intensity-modulated radiotherapy Prescription dose Nasopharyngeal carcinoma |
| FundProject:国家自然科学基金(81301298,81271699,81301936,81472811);中国博士后科学基金(2015M571647);山东省自然科学基金(ZR2013HL044) |
| Author Name | Affiliation | E-mail | | Gu Jiabing | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Zhu Jian | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | zhujian.cn@163.com | | Wei Yumei | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Gong Guanzhong | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Ma Changsheng | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | | | Yin Yong | Department of Radiation Oncology Physicist, Shandong Cancer Hospital and Institute
Shandong Provincial Key Laboratory of Radiation Oncology, Jinan 250117, China | |
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| Abstract:: |
| Objective To study the feasibility of helical tomoterapy (HT) at prescription dose escalation for nasopharyngeal carcinoma (NPC). Methods Static-IMRT (sIMRT) and HT plans were designed for 10 nasopharyngeal carcinoma patients which were treated by sIMRT and HT treatment plan. Prescription dose was escalated for each plan until any organs at risk (OARs) reached the quantitative analysis of normal tissue effects within the clinical threshold. Dosimetric factors of target and OARs were analyzed for both sIMRT and HT plans. Results Compared with sIMRT plan, prescribed dose of HT plans increased 42.6% (t=6.373, P<0.01), and the homogeneity index was also improved (t=-2.288, P<0.05); the conformity index decreased (P>0.05). The limits of HT prescribed dose escalation were spinal cord (2 cases), optic nerve (5 cases) and brainstem (3 cases). The limits of sIMRT prescribed dose escalation were lens (1 case), spinal cord (1 case) and parotid (8 cases). Conclusions HT could improve prescription dose of nasopharyngeal carcinoma while keeping the OARs safe. Compared with sIMRT, HT technology might be used at high dose NPC radiotherapy. |
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