| Wang Jiahao,Li Xiadong,Deng Qinghua,Wu Zhibing,Xia Bing,Lai Jianjun,Tang Rongjun.Dosimetric comparison of two arcs VMAT plan and IMRT plan for breast cancer post-mastectomy[J].Chinese Journal of Radiological Medicine and Protection,2014,34(12):942-945 |
| Dosimetric comparison of two arcs VMAT plan and IMRT plan for breast cancer post-mastectomy |
| Received:February 07, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.12.019 |
| KeyWords:Volumetric modulated arc therapy(VMAT) Intensity modulated radiation therapy(IMRT) Dosimetry |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wang Jiahao | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | | | Li Xiadong | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | hehe8812@126.com | | Deng Qinghua | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | | | Wu Zhibing | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | | | Xia Bing | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | | | Lai Jianjun | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | | | Tang Rongjun | Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou 310000, China | |
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| Abstract:: |
| Objective To analyze the biophysical dosimetric characteristics and clinical application ability of VMAT technology for breast cancer post-mastectomy. Methods 28 patients with breast cancer (10 at left side and the other at right side) were planned in different ways respectively. One was two 90 degree arc VMAT plan and the other were 5 beam IMRT plan. The dosimetric parameters of two different plans including tumor control probability (TCP),conformity index(CI), homogeneity index(HI),V95 and V110 in target, normal tissue complication probability(NTCP),V-5, V20, V30 for ipsilateral lung, NCTP, Dmean, V25 for heart, Dmean for the contralateral breast in OARs, MU and times were compared. Results The average tumor control probability (TCP) in VMAT and IMRT group was(96±2)% and (90±2)% (t=-6.28, P<0.01), respectively. The PTV dose average homogeneity index (HI) of VMAT plans was better than that of IMRT plan (0.15±0.04 vs 0.22±0.02, t=13.29, P <0.01). For cancer position in left side, the mean dose of heart was decreased by 433.24 cGy in the VMAT plan. The NTCP of the hearts in VMAT plans had statistically significant difference compared with IMRT plans [(1.00±0.12)% vs (1.70±0.13)%, t=2.14,P<0.05]. For plans of right breast cancer,the average mean dose of hearts in two control group was (3.27±0.26) Gy and (6.00±0.47)Gy (t=9.21,P<0.01). The total monitor unit (MU) was 530.7 in the VMAT arm and 693.9 in the IMRT arm (t=9.58,P <0.01). The treatment time was shorter in VMAT arm (t=8.40,P<0.05). Conclusions VMAT plans have better clinical value and more superior biophysical dosimetric characteristics for breast cancer post-mastectomy. |
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