| He Changjiu,Ren Jing,Xu Guohui,Hou Junmin,Wang Min,Pang Huarong,Dong Xiaolei,He Yakun,Li Hailie.Study on predicting and evaluating the effect of chemo-radiation therapy in cervical cancer by diffusion-weighted magnetic resonance imaging[J].Chinese Journal of Radiological Medicine and Protection,2014,34(11):841-844 |
| Study on predicting and evaluating the effect of chemo-radiation therapy in cervical cancer by diffusion-weighted magnetic resonance imaging |
| Received:May 12, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.11.010 |
| KeyWords:DWI Cervical cancer Chemo-radiation therapy Prediction Evaluation |
| FundProject: |
| Author Name | Affiliation | E-mail | | He Changjiu | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Ren Jing | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Xu Guohui | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | XGH0913@hotmail.com | | Hou Junmin | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Wang Min | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Pang Huarong | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Dong Xiaolei | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | He Yakun | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | | | Li Hailie | Department of Medical Imaging, Sichuan Cancer Hospital, Chengdu 610041, China | |
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| Abstract:: |
| Objective To investigate the value in application of diffusion-weighted magnetic resonance imaging on predicting and evaluating the efficacy of chemo-radiation therapy in cervical cancer.Methods To tally 282 patients with cervical cancer diagnosed by pathological examination were examined before and after treatments using DWI, while the ADC values and the max diameters were measured. The patients were divided into ease and invalid group on the basis of Response Evaluation Criteria In Solid Tumors (RECIST)after treatments, and divided into recurrence and non recurrence group according to 2- year follow-ups after treatments. The ADC value before and after treatment between the two groups were compared respectively, and correlation test was performed. Results The patients were divided into ease group (223 cases) and invalid group (59 cases), recurrence group (70 cases) and non recurrence group (212 cases). The ADC values of ease group were significantly lower than invalid group before treatments(t=3.274,P<0.05),which of non recurrence group were significantly lower than recurrence group before treatments(t=1.031,P<0.05). The recurrence rates of patients with low ADC values before treatments were significantly lower than the patients with high ADC values before treatments(χ2=5.175,P<0.05).The efficacy after treatment for 2 months and follow-ups after treatment for 2 years were both negative correlated with the ADC value before treatment(r=-0.571, -0.675,P<0.05), and positively correlated with the elevated ADC value after treatment(r=0.641, 0.547,P<0.05).The ADC values after treatments of ease group and non recurrence group increased significantly (t=2.031, 4.011, P<0.05), however, invalid group and the recurrence group increased insignificantly. Conclusions The ADC value before treatment can be used to predict curative effect of chemo-radiation therapy in cervical cancer, while the changes of ADC value after treatment are able to evaluate the efficacy of the treatment. |
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