| Zhu Shuchai,Dong Hui,Shen Wenbin,et al.The concurrent control study of elective nodal prophylactic irradiation with intensity modulated radiotherapy for esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2014,34(10):758-762 |
| The concurrent control study of elective nodal prophylactic irradiation with intensity modulated radiotherapy for esophageal carcinoma |
| Received:February 18, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.10.009 |
| KeyWords:Esophageal carcinoma Radiotherapy Elective nodal prophylactic irradiation Involved-field irradiation Concurrent control |
| FundProject:河北省医学适用技术跟踪项目（GL200848） |
| Author Name | Affiliation | E-mail | | Zhu Shuchai | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | sczhu1965@163.com | | Dong Hui | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Shen Wenbin | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Liu Zhikun | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Li Juan | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Su Jingwei | Department of Radiation Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective: To explore the value of elective nodal prophylactic irradiation with intensity modulated radiotherapy(IMRT) for esophageal carcinoma. Screening patients who are suitable for elective nodal prophylactic irradiation (ENI), in order to improve locoregional control and overall survival. Methods: The concurrent control study was conducted to esophageal cancer patients who were treated by definitive radiotherapy. A total of 148 patients finished treatment were identified. Seventy-four patients received ENI, while the other seventy-four patients received involved-field irradiation (IFI). Kaplan-Meier method was used for calculation of locoregional control rates and overall survival rates. The univariate and multivariate analysis of prognostic factors were also tested. Results: The 1-, 3-, and 5- year locoregional control rates of ENI group and IFI group were 72.5%, 52.8%, 50.6% and 58.4%, 35.8%, 21.9% (χ2=7.881, P<0.05), respectively. The 1, 3, and 5 years survival rates of the ENI group and IFI group were 74.3%, 44.2%, 24.5% and 68.9%, 27.6%, 15.9% (χ2=1.903, P<0.05), respectively. In Cox multivariate analysis, clinical T stage, tumor location, different radiotherapy region were independent factors for the locoregional control of all patients, and clinical T, N stage, the length of esophageal barium meal and chemotherapy were independent factors for the overall survival of all patients. Conclusions: Esophageal carcinoma patients treated with ENI could achieve better locoregional control than those treated with IFI. Esophageal carcinoma patients with early stage or middle thoracic lesion could benefit from ENI for local control and overall survival. |
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