| Duan Yili,Li Jianbin,Zhang Yingjie,et al.Comparison of 4D-CT and PET-CT based internal gross tumor volumes delineation for non-small-cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2014,34(10):753-757 |
| Comparison of 4D-CT and PET-CT based internal gross tumor volumes delineation for non-small-cell lung cancer |
| Received:December 22, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.10.008 |
| KeyWords:Non-small cell lung cancer Fluorodeoxyglucose positron emission tomography computed tomography Four-dimensional computed tomography Internal gross target volume Standardized uptake value |
| FundProject:国家自然科学基金青年基金（81201735）；山东省科技发展计划项目（2012GSF11839）；山东省自然科学基金（ZR2011HM004） |
| Author Name | Affiliation | E-mail | | Duan Yili | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Li Jianbin | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | lijianbin@msn.com | | Zhang Yingjie | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Wang Wei | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Li Fengxiang | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Guo Yanluan | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Fu Zheng | 250117 济南, 山东省肿瘤医院PET-CT室 | | | Shang Dongping | 250117 济南, 山东省肿瘤医院大孔径CT定位室 | |
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| Abstract:: |
| Objective: To compare the positional and volumetric differences of internal gross target volumes (IGTVs) delineation based on four-dimensional CT (4D-CT) images and different standardized uptake values of 18F-fluorodeoxyglucose positron emission tomography CT (PET-CT) for the primary non-small cell lung cancer (NSCLC). Methods: Ten NSCLC patients underwent enhanced three-dimensional CT scan followed by enhanced 4D-CT scan of the thorax under normal free breathing and then 18F-FDG PET-CT scan was performed based on the same position and positioning parameters. The gross target volumes (GTVs) of 10 phases of 4D-CT were contoured and IGTV10 was obtained by fusion of the 10 GTVs. IGTVPET were determined with nine different threshold methods using the auto-contouring function and manual contouring. The differences of position, volume, degree of inclusion (DI) and conformity index (CI) between IGTVPET and IGTV10 were compared. Results: For superior-inferior (SI) directions, there were statistically significant differences between the centric coordinate parameters of IGTVPET (excluding IGTVPET1.5) and IGTV10 (Z=-2.703--2.293, P<0.05). In volume terms, IGTVPET2.0 was approximated close to IGTV10 with median volume ratios of 0.90, followed by IGTVPET20% to IGTV10 with median volume ratios of 0.84, but there was no significant difference between them. The DI of IGTVPET1.5 in IGTV10 was higher than the DIs of other IGTVPET in IGTV10 (Z=-2.803--2.429, P<0.05). The CI of IGTVPET2.0 and IGTV10 was superior than the CIs of IGTVPET35% and IGTV10, IGTVPET40% and IGTV10, IGTVPET2.5 and IGTV10, IGTVPET3.0 and IGTV10 (Z=-2.803--2.191, P<0.05). Conclusions: The IGTVPET contoured by SUV≥2.0 or 20% of the maximal SUV are approximate close to IGTV10 in target size, but the extent of spatial mismatch is relatively obvious between them. So neither IGTVPET20% nor IGTVPET2.0 could replace IGTV10 . |
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