| Zhu Jincan,Chen Xiaoyu,Liu Chengcheng,et al.Effect of salidroside on radiation-induced bone marrow adipogenesis[J].Chinese Journal of Radiological Medicine and Protection,2014,34(10):735-738 |
| Effect of salidroside on radiation-induced bone marrow adipogenesis |
| Received:March 18, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.10.004 |
| KeyWords:Radiation Adipocyte Bone marrow microenvironment Salidroside |
| FundProject:国家自然科学基金（81270568） |
| Author Name | Affiliation | E-mail | | Zhu Jincan | Institute of Hematology, Jinan University, Guangzhou 510632, China | | | Chen Xiaoyu | Institute of Hematology, Jinan University, Guangzhou 510632, China | | | Liu Chengcheng | Institute of Hematology, Jinan University, Guangzhou 510632, China | | | Zhu Aizhen | Institute of Hematology, Jinan University, Guangzhou 510632, China | | | Liu Shantao | Institute of Hematology, Jinan University, Guangzhou 510632, China | | | Liu Gexiu | Institute of Hematology, Jinan University, Guangzhou 510632, China | tliugx@jnu.edu.cn |
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| Abstract:: |
| Objective: To investigate the potential and underlying molecular mechanism of salidroside in ameliorating radiation-induced bone marrow adipogenesis and stimulating hematopoiesis. Methods: The female BALB/c mice aged 6-7 weeks were randomly divided into normal control group, radiation group and salidroside group. The radiation group and salidroside group were irradiated with 6.0 Gy of 60Co γ-rays. The salidroside group was intraperitoneally injected with 30 mg·kg-1·d-1 salidroside at 12 h and then every day until 8th d after radiation. The normal control group and radiation group were treated with equal volume of saline as control of salidroside. At 14 d after radiation, the mice weight, peripheral blood count, femur bone marrow histology, and the proportion of adipocyte area were measured, and the expressions of PPAR-γ and FABP4 were detected by q-PCR. Results: After irradiation, the numbers of white blood cells, hemoglobin and platelet in peripheral blood were reduced obviously, and the percentage of adipocyte area was increased significantly. Compared with mice in the radiation group, salidroside inhibited adipogenesis and reduced the proportion of adipocyte area (t=13.31, P<0.05) by reducing the expressions of PPAR-γ and FABP4 (t=8.64, 13.19, P<0.05). The number of white blood cells was partly recovered at 7 d after irradiation (t=5.80, P<0.05). Both white blood cells and hemoglobinin in peripheral blood of the salidroside group were higher than those in the radiation group at 14 d after irradiation. Conclusions: Salidroside could inhibit radiation-induced bone marrow adipogenesis and regulate bone marrow microenvironment, thereby promotes hematopoietic recovery in mice after radiation injury. |
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