| Ma Yidong,Hu Man,Lu Jie,et al.Preliminary investigation of 18F-FDG and 18F-FETNIM PET-CT applied in head and neck cancer patients undergoing biological intensity modulated radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2014,34(8):601-605 |
| Preliminary investigation of 18F-FDG and 18F-FETNIM PET-CT applied in head and neck cancer patients undergoing biological intensity modulated radiotherapy |
| Received:December 15, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.08.010 |
| KeyWords:Head and neck cancer 18F-FDG PET-CT 18F-FETNIM PET-CT Biological intensity modulated radiotherapy |
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| Abstract:: |
| Objective To evaluate the feasibility of using Fluorine-18 fluorodeoxyglucose (18F-FDG) and Fluorine-18 fluoroerythronitroimidazole (18F-FETNIM) in positron emission tomography with computed tomography (PET-CT) to define biological target volume during the biological intensity modulated radiotherapy (BIMRT). Methods Twelve patients with pathologically confirmed head and neck cancer were scanned with CT simulation, 18F-FDG PET-CT and 18F-FETNIM PET-CT respectively before treatment. Three gross target volumes, GTVCT, GTVFDG and GTVFETNIM, were delineated correspondingly with three modalities. The volumes of primary tumor (P-) and metastatic lymph nodes (N-), denoted as GTVP-CT, GTVN-CT, GTVP-FDG, GTVN-FDG, GTVP-FETNIM and GTVN-FETNIM, were compared respectively. Results Both primary tumor and metastatic lymph node of the 12 patients had 18F-FDG uptake, and the average maximal standard uptake values (SUVmax) were 12.3±5.5 and 5.1±2.8, respectively. Positive primary tumor 18F-FETNIM uptake was observed in 9 patients, yet only 5 of whom had positive 18F-FETNIM uptake in lymph node metastases. Three patients had no 18F-FETNIM uptake in the primary tumor, among whom 1 had positive 18F-FETNIM uptake in lymph node metastases. The volumes of GTVP-CT, GTVP-FDG and GTVP-FETNIM were (22.23±12.11), (20.83±11.59) and (1.98±1.81) cm3, respectively. The volumes of GTVN-CT, GTVN-FDG and GTVN-FETNIM were (10.77±8.87), (10.41±8.61) and (0.61±1.08) cm3, respectively. Compared to CT imaging, the volume differences of primary tumor and metastatic lymph nodes shown on 18F-FDG PET-CT imaging were statistically not significant. Compared with CT and 18F-FDG PET-CT, the corresponding volumes were significantly smaller at 18F-FETNIM PET-CT (P<0.01). Conclusions The study demonstrated that PET-CT imaging using different tracers may define subregions of the tumor for biological target volume delineation, which provides foundations for BIMRT. |
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