| Li Jinhui,Liu Junye,Jiang Dapeng,et al.Effect of EMP on sex ratio of the offspring of male BALB/c mice[J].Chinese Journal of Radiological Medicine and Protection,2014,34(8):588-591 |
| Effect of EMP on sex ratio of the offspring of male BALB/c mice |
| Received:March 10, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.08.007 |
| KeyWords:Electromagnetic pulse Testis index Sperm number Offspring sex ratio |
| FundProject:国家重点基础研究发展计划（973计划）（2011CB503704）；国家自然科学基金（51277175，81072272） |
| Author Name | Affiliation | E-mail | | Li Jinhui | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Liu Junye | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Jiang Dapeng | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Miao Xia | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Wang Yafeng | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Guo Qiyan | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | | | Guo Guozhen | Department of Radiation Medicine, the Fourth Military Medical University, Xi'an 710032, China | guozhen@fmmu.edu.cn |
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| Abstract:: |
| Objective To investigate the effects of EMP exposure to male BABL/c mice on the reproduction and its sex ratio. Methods Thirty-three male BALB/c mice were randomly divided into sham-exposed group, 10 000 pulses/d exposed group, and 100 000 pulses/d exposed group with 50 Hz static magnetic field of 35 kV/m for 2 weeks consecutively, then the male mice were mated with unexposed females (1 male vs. 2 female). Mated males were sacrificed to examine the exposure effects on sperm number and testis index after 7 days of mating. The sex ratio of embryos collected from unexposed mated females was investigated by PCR. Results The sex ratio of offspring was 0.298 (14/47) in the 10 000 pulses/d exposed group, significantly lower than 0.871 (27/31) in the sham-exposed group. No statistical changes were observed in the sex ratio of offspring, sperm number, the weights of testis and testis index after 100 000 pulses/d exposure. Conclusions The exposure of male mice to 35 kV/m EMP at 10 000 pulses/d for 2 weeks consecutively may change the sex ratio of mice's offspring. |
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