| Qin Xiujun,Yin Jingjing,Xu Wenli,Yuan Hui,Wei Jinping,Li Jianguo,An Quan.Protective effects of different doses of hydrogen-rich water on radiation injury in mice[J].Chinese Journal of Radiological Medicine and Protection,2014,34(8):578-582 |
| Protective effects of different doses of hydrogen-rich water on radiation injury in mice |
| Received:December 27, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.08.005 |
| KeyWords:Hydrogen-rich water Gamma rays ICR mice Radiation injury |
| FundProject: |
| Author Name | Affiliation | E-mail | | Qin Xiujun | China Institute for Radiation Protection, Taiyuan 030006, China | | | Yin Jingjing | China Institute for Radiation Protection, Taiyuan 030006, China | | | Xu Wenli | China Institute for Radiation Protection, Taiyuan 030006, China | | | Yuan Hui | China Institute for Radiation Protection, Taiyuan 030006, China | | | Wei Jinping | China Institute for Radiation Protection, Taiyuan 030006, China | | | Li Jianguo | China Institute for Radiation Protection, Taiyuan 030006, China | | | An Quan | China Institute for Radiation Protection, Taiyuan 030006, China | anquan@cirp.org.cn |
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| Abstract:: |
| Objective To observe the protective effects of different doses of hydrogen-rich water on radiation injury in mice, so as to provide scientific basis for the application of hydrogen-rich water. Methods The ICR mice were randomly divided into control group, irradiation group, amifostine group and hydrogen-rich water of low, medium and high dose groups. The 30 days survival rate, body weight, hematology parameters, serum biochemical parameters, organ weight and coefficient, bone marrow micronucleus rate, bone marrow nucleated cell count were observed after total body irradiation with 9.0 Gy gamma rays. Results After 30 d of irradiation, the hydrogen-rich water showed obvious protective effect on the survival rate and body weight in a dose dependent manner so that the survival was significantly higher than that of irradiation group (t =-2.67, P<0.05). The biochemical index, such as TP, ALB and CRE in the low dose group, TP, ALB, TBIL and CRE in the medium dose group, and TP, ALB, GLU, TBIL, BUN, GRE and UA in the high dose group also indicated the protective effects of hydrogen-rich water (t=-2.04－-4.11, P<0.05). But the protective effect of hydrogen-rich water was not observed in hematology, organ weight and coefficient, and bone marrow micronucleus induction. Conclusions The hydrogen-rich water has anti-radiation effect, which may depend on the dose of hydrogen. |
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