| Deng Chong,Lin Qin,Shi Liwan,et al.The suitable uptake value threshold of 18F-FDG PET/CT image on gross tumor volume delineation of nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2014,34(7):530-534 |
| The suitable uptake value threshold of 18F-FDG PET/CT image on gross tumor volume delineation of nasopharyngeal carcinoma |
| Received:November 07, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.07.013 |
| KeyWords:18FDG PET/CT Nasopharyngeal carcinoma Gross tumor volume Delineation |
| FundProject: |
| Author Name | Affiliation | E-mail | | Deng Chong | Department of Radiation Oncology, Cancer Center of First Affiliated Hospital of Xiamen University, Xiamen 361003, China | | | Lin Qin | Department of Radiation Oncology, Cancer Center of First Affiliated Hospital of Xiamen University, Xiamen 361003, China | | | Shi Liwan | Department of Radiation Oncology, Cancer Center of First Affiliated Hospital of Xiamen University, Xiamen 361003, China | | | Zhu Luchao | Department of Radiation Oncology, Cancer Center of First Affiliated Hospital of Xiamen University, Xiamen 361003, China | | | Tian Ye | 苏州大学附属第二医院放疗科 | dryetian@hotmail.com |
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| Abstract:: |
| Objective To define a suitable threshold setting for gross tumor volume (GTV)when using 18F-fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in Nasopharyngeal carcinoma(NPC).Methods Sixteen NPC patients respectively received PET/CT and MRI scan before their radiation treatment. All of the images were transferred to the radiotherapy planning system (TPS). MRI/CT-based primary GTV was defined as GTVf. Biological target volumes (BTVs) were derived from PET/CT-based GTVs of primary tumors. The BTVs were defined as the volumes when adjusting different percentage of the maximal standardized uptake value (SUVmax). GTVfs were compared with BTVs. The suitable threshold level (sTL) could be determined when BTV value and its morphology using a certain threshold level were observed to be the fittest GTVf. The suitable standardized uptake value (sSUV) was calculated as the sTL multiplied by the SUVmax. Results Our result demonstrated no single sTL or sSUV method could achieve an optimized volumetric match with the GTVf. The sTL was[20.93%±6.51％(15%-40%)], whereas the sSUV was[2.27±0.48(1.56-3.25)]. The sTL was inversely correlated with the SUVmax , sTL=-0.144ln(SUVmax)+0.5548(R2=0.85,F=78.57, P<0.01. The sSUV showed a linear correlation with the SUVmax,sSUV=0.104(SUVmax)+ 1.0398,(R2=0.75,F=41.88,P<0.01). The sTL was not associated with the value of GTVf. Conclusions In PET/CT-based BTV for NPC, SUVmax threshold method is feasible. sTL is not a fixed value, which is correlated with the SUVmax instead of the value of tumor. |
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