| Qi Xin,Gao Xianshu,Li Feiyu,et al.The optimal clinical target volume for the seminal vesicle in localized prostate cancer radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2014,34(7):518-522 |
| The optimal clinical target volume for the seminal vesicle in localized prostate cancer radiotherapy |
| Received:March 10, 2014 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.07.010 |
| KeyWords:Prostate cancer Radiotherapy Seminal vesicle Target delineation CT reconstruction |
| FundProject: |
| Author Name | Affiliation | E-mail | | Qi Xin | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Gao Xianshu | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | gao7777@139.com | | Li Feiyu | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Zhang Min | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Li Hongzhen | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Li Xiaomei | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Wang Qingguo | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Qin Shangbin | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Ma Mingwei | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Wang Xiaoying | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Wang Dian | Department of Radiation Oncology, Rush University Medical Center | |
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| Abstract:: |
| Objective To discuss the clinical target volume (CTV) for the seminal vesicle (SV) in localized prostate cancer radiotherapy.Methods Radiotherapy planning CT images from 114 patients with intermediate- or high-risk prostate cancer were collected and reconstructed at a thickness of 1 mm. Cross sections of the SV, 1.0 and 2.0 cm from the starting point, were located. Then, the maximum (D10H, D20H) and minimum (D10L, D20L) distance from these two cross sections to the initial plane of the SV were measured the proximal SV included in the high-dose CTV based on EORTC prostate cancer radiotherapy guideline and the current RTOG 0815 protocol guideline and the anatomic volume of proximal 1 and 2 cm SV were compared. Results The distance of D10H, D10L, D20H and D20L were (10.6 ± 1.8), (2.1 ± 2.0), (17.2 ± 2.9) and (8.8 ± 2.7)mm, D10H and D20H that can include 95% of the patients were 13.5 mm and 21.4 mm respectively. A smaller SV tilt angle (α and β) and a larger diameter of the cross section (R10/20) were associated with a longer D10H (R2=0.64, P<0.01) or D20H (R2=0.77, P<0.01). When it was defined 1.0 cm vertically upward from the initial plane as the upper limit of the CTV, the proximal 1.0 cm of the SV could not been entirely encompassed in 65.8%(75/114) of the enrolled cases. The proximal 2.0 cm of the SV could not been entirely encompassed in 17.5%(20/114) of our cases when 2.0 cm as the upper limit were used. Conclusions In order to contouring anatomic 1.0 cm/2.0 cm SV, the high-dose CTV need to extend 1.4 cm/2.2 cm upward for the anteromedial portion of the SV, and 0.5 cm/1.4 cm for the posterolateral SV. |
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