| Yan Hao,Wang Hui,Zhang Heng.The protective effects of resveratral on acute radiation injury in mice[J].Chinese Journal of Radiological Medicine and Protection,2014,34(7):512-515 |
| The protective effects of resveratral on acute radiation injury in mice |
| Received:July 23, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.07.008 |
| KeyWords:Radiation enteritis Resveratrol Small intestinal crypt cells |
| FundProject:天津市中医药管理局中医中西医结合专项课题（13131） |
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| Abstract:: |
| Objective To study the protective function of resveratrol on radiation-induced small intestine injury and lethal effect in mice.Methods Mice were randomly divided into three groups: irradiation (IR) control, IR only, and IR+ resveratrol. 15 mice each group were irradiated on abdomen with 7.2 Gy γ-rays for cell lethal assay and 8 mice each group were irradiated with 6.5 Gy for small intestine injury assay. For the IR+ resveratrol group, the mouse was given resveratrol by intragastric administration 24 h before irradiation and then was fed with resveratrol daily for 5 days. The control and IR alone groups were fed with placebo. After 30 days of IR, mouse survival rate was detected. For small intestine injury experiments, 24 h after IR, the mice were terminated and the small intestines were treated with HE and immunohistochemical staining. Results Compared with the irradiation group, resveratrol increased mouse survival by 33.3%, decreased apoptosis in intestinal crypt cells (t=17.35, P<0.05), and increased Ki67 expression (t=13.62, P<0.05).Conclusion Resveratrol could protect small intestine injury from ionizing irradiation. |
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