| Huan Jiale,Xing Pengfei,Xu Yingying,et al.The selection of irradiation volume for neck lymph node-negative nasopharyngeal carcinoma：the results based on a Meta-analysis study[J].Chinese Journal of Radiological Medicine and Protection,2014,34(4):275-278 |
| The selection of irradiation volume for neck lymph node-negative nasopharyngeal carcinoma：the results based on a Meta-analysis study |
| Received:September 02, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.04.009 |
| KeyWords:Nasopharyngeal neoplasm Neck lymph node metastasis Radiation target volume Meta-analysis |
| FundProject:江苏省“科教兴卫”医药重点人才项目（RC 2011144）；江苏高校优势学科建设工程项目（PAPD） |
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| Abstract:: |
| Objective To study the appropriate neck irradiation volume for neck lymph node-negative nasopharyngeal carcinoma patients by Meta-analysis. Methods The related references published from Jan 1990 to Jun 2013 were searched in Pubmed, Embase, Cochrane and Wangfang Databases. The qualified references for enrollment criteria were screened and the relative data were collected. The OR (Odds ratio) value by fixed effect model was used to evaluate the data for patients who received radiotherapy between the upper neck and whole neck irradiation. The endpoints including 5-year neck local control rate (LCR), neck-in-irradiation LCR, and neck-outsides-irradiation LCR. Results Five qualified references were screened and belonged to respective research. There enrolled 1 333 patients, including 970 patients who received the upper neck irradiation and 363 patients who received the whole neck irradiation, respectively. The forest plots revealed that there were no significant differences for 5-year neck LCR, neck-in-irradiation LCR, and neck-outsides-irradiation LCR for patients received radiotherapy between the upper neck and whole neck irradiation. These OR values were 0.89 (95%CI: 0.41-1.94), 1.29 (95%CI: 0.58-2.88) and 0.42 (95%CI: 0.07-2.36), respectively. Conclusions The Meta-analysis results suggest that irradiation to the upper neck for neck lymph node-negative nasopharyngeal carcinoma can be appropriate. |
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