| Jiang Jing,Gao Lu,Huang Bo,et al.Effect of low-dose radiation on frequencies of chromosome aberrations and micronucleus-containing cells of occupationally exposed individuals：a Meta analysis[J].Chinese Journal of Radiological Medicine and Protection,2014,34(4):250-254 |
| Effect of low-dose radiation on frequencies of chromosome aberrations and micronucleus-containing cells of occupationally exposed individuals：a Meta analysis |
| Received:August 03, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.04.003 |
| KeyWords:Radiological workers Ionizing radiation Chromosome aberrations Micronucleus cells Meta analysis |
| FundProject:国家863项目（2012AA063501）；国家自然科学基金（81272994） |
| Author Name | Affiliation | E-mail | | Jiang Jing | Academy of Environmental Medicine and Radiation Health, University of South China, Hengyang 421001, China | | | Gao Lu | Academy of Environmental Medicine and Radiation Health, University of South China, Hengyang 421001, China | | | Huang Bo | Academy of Environmental Medicine and Radiation Health, University of South China, Hengyang 421001, China | | | Zhou Pingkun | 军事医学科学院 | | | Rang Weiqing | Academy of Environmental Medicine and Radiation Health, University of South China, Hengyang 421001, China | nhurwq@126.com |
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| Abstract:: |
| Objective To quantitatively investigate the effect of low-dose ionizing radiation on the frequencies of chromosome aberrations and micronucleus-containing cells of radiation workers. Methods Nine electronic databases were systematically searched on the basis of the published studies evaluating the effects of low-dose ionizing radiation on the frequencies of chromosome aberrations and micronucleus-containing cells. Of the 195 studies searched, 21 studies were identified with a total of 1 970 626 cells under studying. Cochrane's Q and I2 statistics were used to evaluate heterogeneity among studies and pooling odds ratio (OR) with 95% confidence intervals (CI) were calculated using random-effect models or fixed-effect models, and publication bias were also calculated. Meta-analysis was performed using Stata 12.0. Results The pooling OR of chromosome-type aberrations [OR=3.03(2.59,3.56)], dicentric plus centric rings [OR=4.12(2.99,5.67)], translocations [OR=2.73(1.67,4.46)], micronucleus-containing cells [OR=1.70(1.40-2.06)] were higher for radiation workers when compared with control group. Conclusions The frequencies of chromosome aberrations and micronucleus cell of peripheral lymphocytes are significantly high in radiation workers who were occupationally exposed to low-dose ionizing radiation. It should be noted that the radiation protection of radiological workers be enhanced. |
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