| Wang Wei,Li Jianbin,Ma Zhifang,et al.Assessment of inter-fractional displacement during the breast intensity modulated radiotherapy based on the on-line Cone Beam CT corrections[J].Chinese Journal of Radiological Medicine and Protection,2014,34(3):192-195 |
| Assessment of inter-fractional displacement during the breast intensity modulated radiotherapy based on the on-line Cone Beam CT corrections |
| Received:May 31, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.03.009 |
| KeyWords:Whole breast intensity modulated radiotherapy Inter-fractional displacement CBCT Setup error Adaptive radiotherapy |
| FundProject:山东省医药卫生科技发展计划项目（2013WS0346）；山东省科技发展计划项目（2012YD18084） |
| Author Name | Affiliation | E-mail | | Wang Wei | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Li Jianbin | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | lijianbin@msn.com | | Ma Zhifang | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Fan Tingyong | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Shao Qian | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Xu Min | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Xing Jun | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Zhang Yingjie | Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China | | | Hu Hongguang | IGRT技术组 | |
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| Abstract:: |
| Objective To explore the inter-fractional geometric uncertainties in breast cancer patients receiving intensity modulated radiotherapy (IMRT) using cone beam CT (CBCT), and to quantify the inter-fractional motion of breast cancer patients. Methods Eighteen breast cancer patients were included in this study, who had received whole breast IMRT after breast conserving surgery. A total of 452 CBCT scans were acquired. Three dimensional inter-fractional motion and setup errors before and after on-line CBCT-based corrections were quantitatively analyzed. The magnitude trends of inter-fractional motion during the treatment were also assessed. Results The magnitudes of the inter-fractional displacements varied among the 18 patients. For the same patient, the disparities in three directions were also different. The maximum inter-fractional variability prior to CBCT-based corrections in the lateral (LR),anteroposterior (AP) and superoinferior (SI) directions were 0.22,0.49 and 0.48 cm respectively, while 0.16, 0.21 and 0.17 cm respectively after on-line CBCT-based corrections. On-line CBCT-based corrections decreased the displacement in SI direction (-0.08 cm vs 0.03 cm, t=-2.373, P<0.05) and random error(t=5.302, 6.689, 4.812,P<0.05), but there were no significant differences for systematic errors. No trends in inter-fractional motion before and after on-line CBCT-based corrections were observed. Conclusions For breast cancer patients who received IMRT, both inter-fractional displacement in SI direction and mean population random errors in three dimensions were reduced after on-line CBCT-based corrections using automatic greyscale match. As a result of individual differences, no significant trend of inter-fractional displacement was identified. |
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