| Li Zichen,Rong Xiaoming,Li Yi,et al.Efficacy of Bevacizumab monotherapy on radiation-induced brian necrosis[J].Chinese Journal of Radiological Medicine and Protection,2014,34(3):188-191 |
| Efficacy of Bevacizumab monotherapy on radiation-induced brian necrosis |
| Received:June 22, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.03.008 |
| KeyWords:Radiation-induced brain necrosis Bevacizumab MRI Efficacy Sides effects |
| FundProject:国家自然科学基金（81272576，81072242）；广东省自然科学基金（S2011010004708）；广州市珠江科技新星项目（2012J2200088）；广东省医学科研基金项目（B2012100） |
| Author Name | Affiliation | E-mail | | Li Zichen | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | | | Rong Xiaoming | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | | | Li Yi | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | | | Fu Ruying | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | | | Xu Pengfei | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | | | Tang Yamei | Department of Neurology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China | yameitang@hotmail.com |
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| Abstract:: |
| Objective To explore the effects and safety of bevacizumab monotherapy on radiation-induced brain necrosis in patients with head and neck cancer. Methods Twenty-three patients with radiation-induced brain necrosis received intravenous injection of bevacizumab 5 mg/kg every 2 weeks for 4 cycles. Before and 2 weeks after the treatment LENT/SOMA scoring system, Montreal Cognitive Assessment (MoCA), and MRI were used to evaluate the scores of subjective and objective items, cognitive scores, and the extent of edema. Adverse effects were observed. Results Two patients suffered from grade 2 rhinorrhagia after the first dose and had to give up the therapy. Twenty-one patients received the full dose of bevacizumab and showed improvement in clinical signs and symptoms. The MoCA score after treatment was significantly higher than that before treatment (t=3.166,P<0. 05). MRI T2-weighted image showed that the volume of brain edema was decreased by (53.9±22.13)% on average (Z=-5.645,P<0.05). One patient showed mild exacerbation of the extent of focus on MRI after the second cycle therapy but still showed significant improvement at the end of four cycles. Of the 21 cases that successfully finished the whole treatment, one suffered from grade 2 rash and one had mild intracranial hemorrhage, however, no grade 3 to 5 adverse reactions were observed. Conclusions Bevacizumab monotherapy may have a rapid and safe therapeutic effect on radiation necrosis. |
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