| Wang Yijun,Zhang Lina,Chang Dongshu,Li Hongqi,Wang Yingjie,Xia Tingyi.The therapeutic effect of stereotactic γ-ray body radiation therapy for patients with asynchronous bilateral renal cell carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2014,34(2):125-128 |
| The therapeutic effect of stereotactic γ-ray body radiation therapy for patients with asynchronous bilateral renal cell carcinoma |
| Received:July 09, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2014.02.012 |
| KeyWords:Renal cell carcinoma Stereotactic γ-ray body radiation therapy Asynchronous bilateral tumor |
| FundProject: |
| Author Name | Affiliation | E-mail | | Wang Yijun | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | | | Zhang Lina | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | | | Chang Dongshu | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | | | Li Hongqi | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | | | Wang Yingjie | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | wangyj9999@163.com | | Xia Tingyi | Department of Radiation Oncology, Air Force General Hospital, Beijing 100142, China | |
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| Abstract:: |
| Objective To preliminarily evaluate the feasibility, therapeutic effect and normal tissue complications of stereotactic γ-ray body radiation therapy for patients with asynchronous bilateral renal cell carcinoma. Methods Nine patients with inoperable asynchronous bilateral renal cell carcinoma with a median time from the resection of the primary focus and discovery of the contralateral focus underwent stereotactic γ-ray body radiotherapy with OUR-QGD stereotactic γ-ray whole body therapeutic planning system. 50% isodose line, as the prescription dose line, was to cover the planning target volume (PTV) and the 70% isodose line was to cover the gross target volume (GTV). Radiotherapy was delivered, with a single dose of 3-5 Gy per fraction, one fraction per day, 5 fractions per week, and totally 10-17 fractions. The PTV edge total dose was 36-51 Gy, and the GTV edge total dose was 60-85 Gy. The patients were followed up for a median time of 24 months to evaluate the local control rate and overall survival rate. Results Of the 9 patients, 1 presented complete remission (11.1%) and 4 partial remission (44.5%), with a total effective rate of 55.6%. The 1-, 3-, and 5-year local control rates were 64.8%, 43.2%, and 43.2% respectively. The 1-, 3-, and 5-year overall survival rates were 66.7%, 53.3%, and 35.6% respectively. Four patients (44.4%) had acute radiation reaction: 2 cases with grade 1 leukocytopenia and 2 cases with grade 1 gastrointestinal reactions. Two patients showed grade 2 late radiation-induced reaction in gastrointestinal system. The Karnofsky score was significantly increased and the renal function was normal after radiotherapy. Conclusions Stereotactic γ-ray body radiation therapy is safe and effective in the treatment of asynchronous bilateral renal cell carcinoma. |
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