| YU Jing-ping,SUN Zhi-qiang,NI Xin-chu,et al.The growth and angiogenesis inhibition effects of thalidomide combined with radiation on the human esophageal carcinoma transplanted nude mice[J].Chinese Journal of Radiological Medicine and Protection,2013,33(6):584-587 |
| The growth and angiogenesis inhibition effects of thalidomide combined with radiation on the human esophageal carcinoma transplanted nude mice |
| Received:March 19, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.06.004 |
| KeyWords:Nude mice Esophageal squamous cell carcinoma Tumor inhibitory rate VEGF Thalidomide |
| FundProject:江苏省卫生厅指导性科研项目（Z201220）；常州市卫生局重大项目（ZD201105）；常州市科技支撑社会发展项目（CE20125021） |
| Author Name | Affiliation | E-mail | | YU Jing-ping | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | SUN Zhi-qiang | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | NI Xin-chu | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | WANG Jian | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | NIE Bin | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | LI Yi | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | HU Li-jun | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | LI Dong-qing | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | MENG Qing-hong | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | | | SUN Su-ping | Department of Radiation Oncology, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China | ssp56@126.com |
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| Abstract:: |
| Objective To evaluate the growth and angiogenesis inhibition effects of thalidomide combined with radiation on the nude mouse transplanted with human esophageal carcinoma cells. Methods Transplant nude mouse model of human esophageal squamous cell carcinoma was established, and 24 nude mice were randomly divided into four groups: healthy control group, thalidomide group, 20 Gy group, and 20 Gy plus thalidomide group. Tumor growth inhibition rates of different groups were calculated. The expressions of vascular epithelial growth factor (VEGF), hypoxia induced factor-1α (HIF-1α) and microvessel density (MVD) were determined by the SP immunohistochemical method. Results Tumor volume and weigth of 20 Gy+TLD group were significantly lower than those in 20 Gy group (t=3.68,4.60,P<0.05). 20 Gy+TLD treatment yielded the highest tumor inhibitory rate of 60.61%. Both VEGF and HIF-1α expressions and MVD value of 20 Gy group were higher than those of 20 Gy+TLD group (t=11.82,6.63,5.92,P<0.01). Conclusions Thalidomide combined with radiation has an increased tumor inhibition effect compared with radiation alone, which may be achieved through VEGF pathway, thalidomide down-regulation of VEGF expression. |
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