| LIANG Ying,WU Ning,GENG Jian-hua,et al.Minimizing radiation dose with PET-CT limited to involved sites in the assessment of postchemotherapy lymphoma[J].Chinese Journal of Radiological Medicine and Protection,2013,33(5):536-539 |
| Minimizing radiation dose with PET-CT limited to involved sites in the assessment of postchemotherapy lymphoma |
| Received:December 11, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.05.023 |
| KeyWords:Lymphoma PET-CT scanning Response assessment Effective dose |
| FundProject: |
| Author Name | Affiliation | E-mail | | LIANG Ying | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | WU Ning | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | cjr.wuning@vip.163.com | | GENG Jian-hua | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | FANG Yan | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | ZHENG Rong | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | ZHANG Wen-jie | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | LIU Ying | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | ZHANG Han | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | | | LI Xiao-meng | PET-CT Center, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China | |
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| Abstract:: |
| Objective To assess PET-CT scanning limited to involved sites in postchemotherapy lymphoma and explore possible radiation dose reductions. Methods Fifty-three lymphoma patients with prechemotherapy and postchemotherapy whole-body PET-CT were analyzed retrospectively. The involved sites were determined on prechemotherapy PET-CT scanning. Whole-body PET-CT scanning and hypothetical PET-CT limited to involved sites were compared in assessing clinical response to chemotherapy. The potential reductions in effective dose and total acquisition time achieved with PET-CT scanning limited to involved sites were calculated. Results Whole-body PET-CT scanning revealed CR in 37 cases, PR in 13 cases and PD in 3 cases in postchemotherapy lymphoma patients, while PET-CT scanning limited to involved sites revealed CR in 37 cases, PR in 14 cases and PD in 2 cases. The mean effective dose was (15.0±1.7) mSv for per patients of CR with whole-body PET-CT scanning, and was (12.0±2.5) mSv for per patients of CR with PET-CT scanning limited in involved sites (Z=-5.307,P<0.05). The mean acquisition time was (19.5±2.6)s for per patients of CR with whole-body PET-CT scanning, and (11.3±4.4)s for per patient of CR with PET-CT scanning limited in involved sites (Z=-5.324,P<0.05).Conclusions Response assessment with PET-CT scanning limited in involved sites has good agreement with whole-body PET-CT scanning in postchemotherapy lymphoma patients with CR. Lymphoma patients with CR may benefit from reduced radiation dose and total acquisition time. PET-CT scanning limited in involved sites is not advisable in patients with PR or PD for poor agreement with whole-body PET-CT scanning in response assessment. |
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