| LI Miao-miao,WANG Yin-xia,HUANG Wei,YIN Yong,GONG Guan-zhong,WANG Dong-qing,LI Bao-sheng.Comparison of dosimetry in radiotherapy for prophylactic cranial irradiation for prophylactic cranial irradiation in small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2013,33(5):493-496 |
| Comparison of dosimetry in radiotherapy for prophylactic cranial irradiation for prophylactic cranial irradiation in small cell lung cancer |
| Received:February 04, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.05.009 |
| KeyWords:Three-dimensional conformal radiotherapy Intensity modulated radiotherapy Prophylactic cranial irradiation Dosimetry |
| FundProject:国家自然科学基金(81272501) |
| Author Name | Affiliation | E-mail | | LI Miao-miao | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | WANG Yin-xia | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | HUANG Wei | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | YIN Yong | 250117 济南大学 医学与生命科学学院, 山东省肿瘤医院物理室 | | | GONG Guan-zhong | 250117 济南大学 医学与生命科学学院, 山东省肿瘤医院物理室 | | | WANG Dong-qing | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | LI Bao-sheng | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | baoshli@yahoo.com |
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| Abstract:: |
| Objective To compare the dosimetric differences among three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and RapidArc for prophylactic carnial irradiation (PCI) in small cell lung cancer (SCLC) patients. Methods Ten patients with SCLC were enrolled into this study. 3D-CRT,9-field IMRT (IMRT) and double arc RapidArc plans were designed and optimized for each patient. The goal was to deliver 25 Gy to ≥ 95% of the planning target volume (PTV) while the same normal-tissue dose constraints were achieved. The dose distribution and conformal index (CI), homogeneity index (HI) of target volume, the maximum dose (D2%), the minimum dose (D98%), target coverage of PTV (V95 and V100), and Dmean and Dmax of organs at risk (OAR) were analyzed by using the dose volume histogram (DVH). The monitor units and delivery time were also evaluated. Results All plans met the clinical requirements. PTV dosimetric parameters(CI, HI, D2%, D98%, V95 and V100)of RapidArc and IMRT were superior to those of 3D-CRT with significant difference (P<0.05). The maximum doses to the optic nerves, brainstem and the mean dose to the parotid glands of the IMRT and RapidArc plans were all significantly lower than those of the 3D-CRT plan (P<0.05), while 3D-CRT plan provided the lowest maximum doses and mean dose of the lens and eyes (P<0.05). Compared with IMRT plan, no obvious advantage in PTV dosimetric parameters could be observed in RapidArc plans. In terms of organ sparing, no statistical difference was observed between IMRT and RapidArc plans. The number of monitor units for 3D-CRT, IMRT and RapidArc were 287.8, 1388.8 and 346.6, respectively. Conclusions Compared with 3D-CRT,IMRT and RapidArc show better dosimetric quality. The 3D-CRT plan has a significantly lower dose on the lens and eyes, less MU and shorter delivery time than IMRT and RapidArc plans. |
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