| LIU Cheng-xin,GONG Guan-zhong,LIU Yu-zhong,LU Jie,LIU Tong-hai,Dong Wei,ZHAO Mu-kun,YIN Yong.To evaluate the irradiation dose of heart based on kV-CBCT and planning CT in the stereotactic body radiotherapy of early stage non-small cell lung cancer (NSCLC)[J].Chinese Journal of Radiological Medicine and Protection,2013,33(5):489-492 |
| To evaluate the irradiation dose of heart based on kV-CBCT and planning CT in the stereotactic body radiotherapy of early stage non-small cell lung cancer (NSCLC) |
| Received:January 17, 2013 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.05.008 |
| KeyWords:Stereotactic body radiotherapy Dosimetry Kilovoltage-cone beam computed tomography Heart |
| FundProject:国家自然科学基金(81272699);山东省自然科学基金(ZR2009CL032,ZR2011HL060) |
| Author Name | Affiliation | E-mail | | LIU Cheng-xin | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | GONG Guan-zhong | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | LIU Yu-zhong | 济南军区空军机关医院放疗科 | | | LU Jie | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | LIU Tong-hai | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | Dong Wei | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | | | ZHAO Mu-kun | 河北大学 | | | YIN Yong | Department of Radiation Oncology, Shandong Cancer Hospital, School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan 250117, China | yongyinsd@163.com |
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| Abstract:: |
| Objective To compare the difference in evaluating the heart irradiation dose based on different heart range contoured on kilovoltage-cone beam computed tomography (kV-CBCT) and planning CT images in stereotactic body radiotherapy (SBRT) of non-small cell lung cancer (NSCLC) at early stage. Methods Fifteen early NSCLC patients who underwent radiotherapy were selected. For every case, kV-CBCT scan was achieved before every fraction treatment to correct the setup error, and the first 10 serious kV-CBCT images were adopted. The heart range on kV-CBCT and planning CT images was contoured and the differences between volume and dose-volume indices were analyzed. Results The heart volume on first kV-CBCT [(717±103)cm3] was larger than that on planning CT [(588±90)cm3] with statistical difference(t=13.8,P<0.05). The relative dose-volume indices: V10Gy-R,V15Gy-R,V20Gy-R,V25Gy-R,V30Gy-R,V35Gy-R obtained on CBCT images were larger than those on planning CT with statistical difference (t=2.3-3.9,P<0.05) expect for V5Gy-R. The absolute dose-volume indices:V5Gy-A,V10Gy-A,V15Gy-A,V20Gy-A,V25Gy-A,V30Gy-A,V35Gy-A obtained on CBCT images were larger than those on planning CT, and all differences were statistically significant(t=4.8-7.9,P<0.05). The dose of certain heart volume Dmean,Dmax,D50cm3,D 100cm3,D150cm3,D200cm3,D250cm3,based on CBCT images were larger than CT images with statistical difference(t=2.9-6.5,P<0.05). Conclusions Based on the characteristics of kV-CBCT and the dose-volume indices of heart, the more accurate and objective dose-volume indices could be obtained through applying kV-CBCT in SBRT of NSCLC. |
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