| SUN Li,XU Kang-xiong,ZHAI Zhen-yu,et al.Follow-up of 5 patients with mycosis fungoides after total skin electron irradiation[J].Chinese Journal of Radiological Medicine and Protection,2013,33(4):400-402 |
| Follow-up of 5 patients with mycosis fungoides after total skin electron irradiation |
| Received:November 23, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.04.016 |
| KeyWords:Mycosis fungoides Total skin electron irradiation Follow-up |
| FundProject: |
| Author Name | Affiliation | E-mail | | SUN Li | Department of Radiation Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China | | | XU Kang-xiong | Department of Radiation Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China | | | ZHAI Zhen-yu | Department of Radiation Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China | | | XU Jian-hua | Department of Radiation Oncology, Jiangsu Cancer Hospital, Nanjing 210009, China | xu016@sohu.com |
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| Abstract:: |
| Objective To report the total skin electron irradiation(TSEI) to treat the mycosis fungoides and the related acute toxicity, short-term efficacy and long-term results. Methods Five patients with pathologically confirmed mycosis fungoides were enrolled from 1990 to 2011, including 4 males and 1 female. Median age was 51 years old(range 14-56 years old). Dose homegeneity within the field were ±10% of the prescribed dose with a skin surface dose of about 90% of the prescribed dose. Four cases received a total dose of about 30 Gy in 30-32 fractions in 8 weeks, and the other case received an electron boost of 5 Gy to the residual tumor after irradiation with 31 Gy within 31 fractions in 8 weeks,who had received 6 cycles chemotherapy before TSEI. Results 4 cases with a follow-up time of more than 15 years achieved complete response 6 months after radiotherapy. For the recently treated case, a great partial response was achieved after radiotherapy. Acute toxicities for all patients were acceptable. Two patients survived after a follow-up of more than 15 years while the other two cases died of visceral involvement at 1 and 3 years later, respectively. The case treated recently survived 2 months later. Conclusions A total TSEI dose of about 30 Gy within 30-32 fractions during 8 weeks could be proved to be very effective and safe in skin lesion control. Visceral involvement is the main failure type. |
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