| HE Xia-yun,GUO Xiao-mao,ZHANG Zhen,et al.Efficacy of conventional radiotherapy and late course accelerated hyperfractionationated radiotherapy for nasopharyngeal carcinoma [J].Chinese Journal of Radiological Medicine and Protection,2013,33(4):392-395 |
| Efficacy of conventional radiotherapy and late course accelerated hyperfractionationated radiotherapy for nasopharyngeal carcinoma |
| Received:July 24, 2012 |
| DOI：10.3760/cma.j.issn.0254-5098.2013.04.014 |
| KeyWords:Nasopharyngeal carcinoma Conventional radiotherapy Late course accelerated hyperfractionated radiotherapy Control rate |
| FundProject: |
| Author Name | Affiliation | E-mail | | HE Xia-yun | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | GUO Xiao-mao | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | shzlfl@gmail.com | | ZHANG Zhen | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | YE Ming | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | PAN Zi-qiang | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | HE Shao-qin | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | | | LIU Tai-fu | Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China | |
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| Abstract:: |
| Objective To compare the efficacy after conventional radiotherapy and late course accelerated fractionation radiotherapy for nasopharyngeal carcinoma (NPC). Methods A total of 200 NPC patients were enrolled and randomly assigned to conventional radiotherapy (CF) group with 99 cases or late course accelerated fractionation radiotherapy (LCAF) group with 101 cases,who received irradiation to 60Co γ or 6 MV X-rays. In the CF group, the total dose of nasopharynx was 70 Gy/35 fractions at 2 Gy daily. In the LCAF group, for the first two-thirds of the treatment, two daily fractions of 1.2 Gy were given to the primary lesion and the total dose was 48 Gy/40 fractions. For the last one third of the treatment, the dose per fraction was increased to 1.5 Gy and the total dose was 30 Gy/20 fractions. Results There were 25, 16, 25 in CF group and 16, 13, 18 patients in LCAF group who had recurrence of nasophaynx, cervical lymph nodes, and distant metastasis, respectively. The 5-year nasopharyngeal control and overall survival rates was 75.9% and 87.6% in CF group (χ2=4.066, P<0.05), 58.0% and 74.1%(χ2=5.076, P<0.05) in LCAF group, respectively. Cervical lymph nodes local rates and distant metastases-free rates at 5 years were 81.5% and 90.0% in CF group(P> 0.05),74.1% and 83.3%(P> 0.05)in LCAF group, respectively. Conclusions Compared with CF, LCAF can improve nasopharyngeal control and overall survival rates, but there are no significant difference in the recurrence rates of cervical lymph nodes and distant metastasis. |
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